Looking back at multidrug resistance (MDR) research and ten mistakes to be avoided when writing about ABC transporters in MDR

被引：26
作者：
Borst, Piet [1 ]
机构：
[1] Netherlands Canc Inst, Div Cell Biol, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands
来源：
FEBS LETTERS | 2020年 / 594卷 / 23期
关键词：
ABC transporters; cancer; grant application; knockout mice; multidrug resistance; GLYCOPROTEIN GENE AMPLIFICATION; P-GLYCOPROTEIN; DRUG-RESISTANCE; LEISHMANIA-TARENTOLAE; INCREASED SENSITIVITY; ORAL BIOAVAILABILITY; CELLULAR-RESISTANCE; MICE LACKING; MOUSE MODEL; EXPRESSION;
D O I：
10.1002/1873-3468.13972
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This paper presents a personal, selective, and sometimes critical retrospective of the history of ABC transporters in multidrug resistance (MDR) of cancer cells, overrepresenting discoveries of some early pioneers, long forgotten, and highlights of research in Amsterdam, mainly focussing on discoveries made with disruptions of ABC genes in mice (KO mice) and on the role of ABC transporters in causing drug resistance in a mouse model of mammary cancer. The history is complemented by a list of erroneous concepts often found in papers and grant applications submitted anno 2020.
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页码：4001 / 4011
页数：11
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