Use of DWI in the Differentiation of Renal Cortical Tumors

被引:55
作者
Hoetker, Andreas M. [1 ,2 ]
Mazaheri, Yousef [3 ]
Wibmer, Andreas [1 ]
Zheng, Junting [4 ]
Moskowitz, Chaya S. [4 ]
Tickoo, Satish K. [5 ]
Russo, Paul [6 ]
Hricak, Hedvig [1 ]
Akin, Oguz [1 ]
机构
[1] Mem Sloan Kettering Canc Ctr, Dept Radiol, New York, NY 10065 USA
[2] Univ Med Mainz, Dept Diagnost & Intervent Radiol, Mainz, Germany
[3] Mem Sloan Kettering Canc Ctr, Dept Med Phys, New York, NY 10065 USA
[4] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10065 USA
[5] Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10065 USA
[6] Mem Sloan Kettering Canc Ctr, Dept Surg, Urol Serv, New York, NY 10065 USA
关键词
cancer; DWI; kidney neoplasms; MRI; renal cell carcinoma; DIFFUSION-WEIGHTED MRI; CELL CARCINOMA; LESIONS; BENIGN; MASSES; ONCOCYTOMA; UTILITY; VALUES;
D O I
10.2214/AJR.14.13923
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
OBJECTIVE. The purpose of this study was to differentiate clear cell renal cell carcinoma (RCC) from other common renal cortical tumors by use of DWI. MATERIALS AND METHODS. The study included 117 patients (mean age, 60 years) with 122 histopathologically confirmed renal cortical tumors who underwent 1.5-T MRI that included DWI before they underwent nephrectomy between 2006 and 2013. For each tumor, two radiologists independently evaluated apparent diffusion coefficient (ADC) values on the basis of a single ROI in a nonnecrotic area of the tumor and also by assessment of the whole tumor. The concordance correlation coefficient (CCC) was calculated to assess interreader agreement. The mean ADC values of clear cell RCC and every other tumor subtype were compared using an exact Wilcoxon rank sum test. RESULTS. Interreader agreement was excellent and higher in whole-tumor assessment (CCC, 0.982) than in single-ROI analysis (CCC, 0.756). For both readers, ADC values for clear cell RCC found on single-ROI assessment (2.19 and 2.08 x 10(-3) mm(2)/s) and whole-tumor assessment (2.30 and 2.32 x 10(-3) mm(2)/s) were statistically significantly higher than those for chromophobe, papillary, or unclassified RCC (p < 0.05) but were similar to those for oncocytoma found on single-ROI assessment (2.14 and 2.32 x 10(-3) mm(2)/s) and whole-tumor assessment (2.38 and 2.24 x 10(-3) mm(2)/s). ADC values were also higher for clear cell RCC than for angiomyolipoma, but the difference was statistically significant only in whole-tumor assessment (p < 0.03). CONCLUSION. ADC values were statistically significantly higher for clear cell RCC than for chromophobe, papillary, or unclassified RCC subtypes; however, differentiating clear cell RCC from oncocytoma by use of DWI remains especially challenging, because similar ADC values have been shown for these two tumor types.
引用
收藏
页码:100 / 105
页数:6
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