Hepatitis B virus pathogenesis: Fresh insights into hepatitis B virus RNA

被引:15
作者
Sekiba, Kazuma [1 ]
Otsuka, Motoyuki [1 ]
Ohno, Motoko [1 ]
Yamagami, Mari [1 ]
Kishikawa, Takahiro [1 ]
Suzuki, Tatsunori [1 ]
Ishibashi, Rei [1 ]
Seimiya, Takahiro [1 ]
Tanaka, Eri [1 ]
Koike, Kazuhiko [1 ]
机构
[1] Univ Tokyo, Grad Sch Med, Dept Gastroenterol, Tokyo 1138655, Japan
关键词
Hepatitis B virus; Hepatitis B virus RNA; MicroRNA; Smc5/6; Viral replication; Hepatic fibrosis; Genome integration; Hepatocellular carcinoma; CLOSED CIRCULAR DNA; HEPATOCELLULAR-CARCINOMA; GENE-EXPRESSION; MESSENGER-RNA; AUSTRALIA-ANTIGEN; TUMOR-SUPPRESSOR; DOWN-REGULATION; LIVER FIBROSIS; HOST MICRORNA; IN-VIVO;
D O I
10.3748/wjg.v24.i21.2261
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Hepatitis B virus (HBV) is still a worldwide health concern. While divergent factors are involved in its pathogenesis, it is now clear that HBV RNAs, principally templates for viral proteins and viral DNAs, have diverse biological functions involved in HBV pathogenesis. These functions include viral replication, hepatic fibrosis and hepatocarcinogenesis. Depending on the sequence similarities, HBV RNAs may act as sponges for host miRNAs and may deregulate miRNA functions, possibly leading to pathological consequences. Some parts of the HBV RNA molecule may function as viral-derived miRNA, which regulates viral replication. HBV DNA can integrate into the host genomic DNA and produce novel viral-host fusion RNA, which may have pathological functions. To date, elimination of HBV-derived covalently closed circular DNA has not been achieved. However, RNA transcription silencing may be an alternative practical approach to treat HBV-induced pathogenesis. A full understanding of HBV RNA transcription and the biological functions of HBV RNA may open a new avenue for the development of novel HBV therapeutics.
引用
收藏
页码:2261 / 2268
页数:8
相关论文
共 57 条
[21]   Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver [J].
Hsu, Shu-hao ;
Wang, Bo ;
Kota, Janaiah ;
Yu, Jianhua ;
Costinean, Stefan ;
Kutay, Huban ;
Yu, Lianbo ;
Bai, Shoumei ;
La Perle, Krista ;
Chivukula, Raghu R. ;
Mao, Hsiaoyin ;
Wei, Min ;
Clark, K. Reed ;
Mendell, Jerry R. ;
Caligiuri, Michael A. ;
Jacob, Samson T. ;
Mendell, Joshua T. ;
Ghoshal, Kalpana .
JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (08) :2871-2883
[22]   The maintenance of chromosome structure: positioning and functioning of SMC complexes [J].
Jeppsson, Kristian ;
Kanno, Takaharu ;
Shirahige, Katsuhiko ;
Sjogren, Camilla .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2014, 15 (09) :601-614
[23]   HBsAg seroclearance after nucleoside analogue therapy in patients with chronic hepatitis B: clinical outcomes and durability [J].
Kim, Gi-Ae ;
Lim, Young-Suk ;
An, Jihyun ;
Lee, Danbi ;
Shim, Ju Hyun ;
Kim, Kang Mo ;
Lee, Han Chu ;
Chung, Young-Hwa ;
Lee, Yung Sang ;
Suh, Dong Jin .
GUT, 2014, 63 (08) :1325-1332
[24]   Hepatitis B virus and microRNAs: Complex interactions affecting hepatitis B virus replication and hepatitis B virus-associated diseases [J].
Lamontagne, Jason ;
Steel, Laura F. ;
Bouchard, Michael J. .
WORLD JOURNAL OF GASTROENTEROLOGY, 2015, 21 (24) :7375-7399
[25]   Viral-Human Chimeric Transcript Predisposes Risk to Liver Cancer Development and Progression [J].
Lau, Chi-Chiu ;
Sun, Tingting ;
Ching, Arthur K. K. ;
He, Mian ;
Li, Jing-Woei ;
Wong, Alissa M. ;
Co, Ngai Na ;
Chan, Anthony W. H. ;
Li, Pik-Shan ;
Lung, Raymond W. M. ;
Tong, Joanna H. M. ;
Lai, Paul B. S. ;
Chan, Henry L. Y. ;
To, Ka-Fai ;
Chan, Ting-Fung ;
Wong, Nathalie .
CANCER CELL, 2014, 25 (03) :335-349
[26]   The Stability Score of the Intramedullary Nailed Intertrochanteric Fractures: Stability of Nailed Fracture and Postoperative Patient Mobilization [J].
Lee, Sung-Rak ;
Kim, Seong-Tae ;
Yoon, Min Geun ;
Moon, Myung-Sang ;
Heo, Jee-Hyun .
CLINICS IN ORTHOPEDIC SURGERY, 2013, 5 (01) :10-18
[27]   Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets [J].
Lewis, BP ;
Burge, CB ;
Bartel, DP .
CELL, 2005, 120 (01) :15-20
[28]   Hepatitis B Virus mRNA-Mediated miR-122 Inhibition Upregulates PTTG1-Binding Protein, Which Promotes Hepatocellular Carcinoma Tumor Growth and Cell Invasion [J].
Li, Changfei ;
Wang, Yanzhong ;
Wang, Saifeng ;
Wu, Bo ;
Hao, Junli ;
Fan, Hongxia ;
Ju, Ying ;
Ding, Yuping ;
Chen, Lizhao ;
Chu, Xiaoyu ;
Liu, Wenjun ;
Ye, Xin ;
Meng, Songdong .
JOURNAL OF VIROLOGY, 2013, 87 (04) :2193-2205
[29]   Removal of Integrated Hepatitis B Virus DNA Using CRISPR-Cas9 [J].
Li, Hao ;
Sheng, Chunyu ;
Wang, Shan ;
Yang, Lang ;
Liang, Yuan ;
Huang, Yong ;
Liu, Hongbo ;
Li, Peng ;
Yang, Chaojie ;
Yang, Xiaoxia ;
Jia, Leili ;
Xie, Jing ;
Wang, Ligui ;
Hao, Rongzhang ;
Du, Xinying ;
Xu, Dongping ;
Zhou, Jianjun ;
Li, Mingzhen ;
Sun, Yansong ;
Tong, Yigang ;
Li, Qiao ;
Qiu, Shaofu ;
Song, Hongbin .
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2017, 7
[30]   ViralFusionSeq: accurately discover viral integration events and reconstruct fusion transcripts at single-base resolution [J].
Li, Jing-Woei ;
Wan, Raymond ;
Yu, Chi-Shing ;
Co, Ngai Na ;
Wong, Nathalie ;
Chan, Ting-Fung .
BIOINFORMATICS, 2013, 29 (05) :649-651