Design, synthesis and evaluation of peroxisome proliferator-activated receptor α/γ dual agonists for the treatment of type 2 diabetes

被引：0

作者：

Das, Saibal Kumar ^{[1
]}

Abbineni, Chandrasekhar ^{[1
]}

Rao, Krovvidi Venkata Lakshmi Narasimha ^{[1
]}

Iqbal, Javed ^{[1
]}

Babu, Ravi Krishna ^{[1
]}

Chakrabarti, Ranjan ^{[1
]}

机构：

[1] Dr Reddys Labs Ltd, Metab Disorders Grp, Discovery Res, Hyderabad 500049, Andhra Pradesh, India

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2007年 / 4卷 / 01期

关键词：

PPAR; diabetes; synthesis; ethyl 3-(4-aminophenyl)-2-ethoxypropionate; dyslipidemia and plasma glucose;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The design, synthesis and evaluation of several dual PPAR alpha/gamma agonists with three different heterocycles, viz. pyrazolo[4,3-d]pyrimidin-7-one, quinazolin-4-one and benzo[e][1,3]oxazine-4-one for the treatment of type 2 diabetes and associated dyslipidemia are described. Among them, compound 5cb was found to possess a potent dual PPAR alpha/gamma agonist property. It significantly reversed diabetic hyperglycemia while improving overall lipid homeostasis in preclinical animal models.

引用

页码：27 / 32

页数：6

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