Synthesis and in vitro antiprotozoal activity of 5-nitrothiophene-2-carboxaldehyde thiosemicarbazone derivatives

被引：64

作者：

Bharti, N

Husain, K

Garza, MTG

Cruz-Vega, DE

Castro-Garza, J

Mata-Cardenas, BD

Naqvi, F

Azam, A

机构：

[1] Jamia Millia Islamia, Dept Chem, New Delhi 110025, India

[2] IMSS, Div Biol Celular Mol, Ctr Invest, Monetary, NL, Mexico

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 23期

关键词：

D O I：

10.1016/S0960-894X(02)00703-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several thiosemicarbazone derivatives of 5-nitrothiophene-2-carboxaldehyde were prepared by the simple process in which N-4-thiosemicarbazone moiety was replaced by aliphatic, arylic and cyclic amine. Among these thiosemicarbazones compound 11 showed significant antiamoebic activity whereas compound 3 was more active antitrichomonal than the reference drug. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：3475 / 3478

页数：4

共 26 条

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