Synthesis and in vitro antiprotozoal activity of 5-nitrothiophene-2-carboxaldehyde thiosemicarbazone derivatives

被引：64
作者：
Bharti, N
Husain, K
Garza, MTG
Cruz-Vega, DE
Castro-Garza, J
Mata-Cardenas, BD
Naqvi, F
Azam, A
机构：
[1] Jamia Millia Islamia, Dept Chem, New Delhi 110025, India
[2] IMSS, Div Biol Celular Mol, Ctr Invest, Monetary, NL, Mexico
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 23期
关键词：
D O I：
10.1016/S0960-894X(02)00703-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Several thiosemicarbazone derivatives of 5-nitrothiophene-2-carboxaldehyde were prepared by the simple process in which N-4-thiosemicarbazone moiety was replaced by aliphatic, arylic and cyclic amine. Among these thiosemicarbazones compound 11 showed significant antiamoebic activity whereas compound 3 was more active antitrichomonal than the reference drug. (C) 2002 Elsevier Science Ltd. All rights reserved.
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页码：3475 / 3478
页数：4
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