Molecular beacon strategies for sensing purpose

被引:53
作者
Bidar, Negar [1 ]
Amini, Mohammad [2 ]
Oroojalian, Fatemeh [3 ,4 ]
Baradaran, Behzad [2 ]
Hosseini, Seyed Samad [1 ]
Shahbazi, Mohammad-Ali [5 ,6 ,7 ]
Hashemzaei, Mahmoud [8 ]
Mokhtarzadeh, Ahad [2 ]
Hamblin, Michael R. [9 ,10 ,11 ]
de la Guardia, Miguel [12 ]
机构
[1] Higher Educ Inst Rab Rashid, Fac Basic Sci, Dept Biol Sci, Tabriz, Iran
[2] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran
[3] North Khorasan Univ Med Sci, Dept Adv Technol, Sch Med, Bojnurd, Iran
[4] North Khorasan Univ Med Sci, Nat Prod & Med Plants Res Ctr, Bojnurd, Iran
[5] Univ Helsinki, Fac Pharm, Div Pharmaceut Chem & Technol, Drug Res Program, FI-00014 Helsinki, Finland
[6] Zanjan Univ Med Sci, Dept Pharmaceut Nanotechnol, Sch Pharm, Zanjan, Iran
[7] Zanjan Univ Med Sci, Zanjan Pharmaceut Nanotechnol Res Ctr ZPNRC, Zanjan, Iran
[8] Zabol Univ Med Sci, Dept Pharmacodynam & Toxicol, Sch Pharm, Zabol, Iran
[9] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA
[10] Harvard Med Sch, Dept Dermatol, Boston, MA 02115 USA
[11] Univ Johannesburg, Laser Res Ctr, Fac Hlth Sci, ZA-2028 Doornfontein, South Africa
[12] Univ Valencia, Dept Analyt Chem, Dr Moliner 50, Valencia 46100, Spain
关键词
Molecular beacon; Nucleic acid probe; Biosensor; 2 '-O-methylated MBs; Peptide nucleic acids; Locked nucleic acids; Aptamer MBs; Catalytic MB; SINGLE-NUCLEOTIDE POLYMORPHISM; UNPROCESSED HUMAN PLASMA; NUCLEIC-ACID; ULTRASENSITIVE DETECTION; SENSITIVE DETECTION; QUANTUM DOTS; INNOVATIVE IMMUNOSENSOR; COLORIMETRIC DETECTION; FLUORESCENT BIOSENSOR; MULTIPLEXED DETECTION;
D O I
10.1016/j.trac.2020.116143
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The improvement of nucleic acid probes as vital molecular engineering devices will cause a noteworthy contribution to developments in bioimaging, biosensing, and disorders diagnosis. The molecular beacon (MB) which was designed by Tyagi and Kramer in 1996, are loop-stem hairpin-designed oligonucleotides armed with a quencher and a dye (also named reporter groups) at the 30 or 50 ends. This construction allows that MBs in the absence of their target complementary molecules do not fluoresce. Through hybridization with their specific targets a spontaneous configuration change on MBs occur and the dye and quencher separate from each other, resulting in emitting the fluorescence. MBs are effective probes for biosensing because of their extraordinary target-specificity, unique structure, inherent fluorescent signal transduction mechanism, low background fluorescence emission, recognition without separation, and favorable thermodynamic properties. In comparison to other probes (such as linear DNA sequences), MBs with the same number of complementary nucleotides matching their target, are multitasking probes. They have advantages of thermodynamic and photostability, flexible ability for conjugation, higher efficient intrinsic signal switching, and ultra-sensitivity. MBs not only are useful for identifying a nucleic acid target but can also be employed for recognition of various non-nucleic acid goals, including heavy metals and cations, enzymes, cells, ATP, etc. Hence, this review highlights the potential of MBs in the improvement of biosensors and their usage in detection of different analytes such as miRNA, mRNA, cocaine, methamphetamine, actin, thrombin, heavy metal and cations and so on. (C) 2020 Elsevier B.V. All rights reserved.
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页数:21
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