Labrenzbactin from a coral-associated bacterium Labrenzia sp.

被引:35
|
作者
Sharma, Amit Raj [1 ,2 ]
Zhou, Tao [1 ,2 ]
Harunari, Enjuro [1 ,2 ]
Oku, Naoya [1 ,2 ]
Trianto, Agus [3 ]
Igarashi, Yasuhiro [1 ,2 ]
机构
[1] Toyama Prefectural Univ, Biotechnol Res Ctr, 5180 Kurokawa, Imizu, Toyama 9390398, Japan
[2] Toyama Prefectural Univ, Dept Biotechnol, 5180 Kurokawa, Imizu, Toyama 9390398, Japan
[3] Diponegoro Univ, Fac Fisheries & Marine Sci, Tembalang Campus,St Prof Soedarto, Sh Semarang 50275, Central Java, Indonesia
来源
JOURNAL OF ANTIBIOTICS | 2019年 / 72卷 / 08期
基金
日本学术振兴会;
关键词
SP NOV; SIDEROPHORE;
D O I
10.1038/s41429-019-0192-x
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
A new catecholate-containing siderophore, labrenzbactin (1), was isolated from the fermentation broth of a coral-associated bacterium Labrenzia sp. The structure and absolute configuration of 1 was determined by spectroscopic methods and Marfey's analysis. Overall, 1 showed antimicrobial activity against Ralstonia solanacearum SUPP1541 and Micrococcus luteus ATCC9341 with MIC values of 25 and 50 mu g ml(-1), respectively, and cytotoxicity against P388 murine leukemia cells with an IC50 of 13 mu M.
引用
收藏
页码:634 / 639
页数:6
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