2-Aminoethoxydiphenyl borate (2-APB) is a reliable blocker of store-operated Ca2+ entry but an inconsistent inhibitor of InsP3-induced Ca2+ release

被引：614

作者：

Bootman, MD ^{[1
]}

Collins, TJ ^{[1
]}

Mackenzie, L ^{[1
]}

Roderick, HL ^{[1
]}

Berridge, MJ ^{[1
]}

Peppiatt, CM ^{[1
]}

机构：

[1] Babraham Inst, Mol Signalling Lab, Cambridge CB2 4AT, England

来源：

FASEB JOURNAL | 2002年 / 16卷 / 10期

关键词：

D O I：

10.1096/fj.02-0037rev

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Since its introduction to Ca2+ signaling in 1997, 2-aminoethoxydiphenyl borate (2-APB) has been used in many studies to probe for the involvement of inositol 1,4,5-trisphosphate receptors in the generation of Ca2+ signals. Due to reports of some nonspecific actions of 2-APB, and the fact that its principal antagonistic effect is on Ca2+ entry rather than Ca2+ release, this compound may not have the utility first suggested. However, 2-APB has thrown up some interesting results, particularly with respect to store-operated Ca2+ entry in nonexcitable cells. These data indicate that although it must be used with caution, 2-APB can be useful in probing certain aspects of Ca2+ signaling.

引用

页码：1145 / 1150

页数：6