Monte Carlo simulation tool for online treatment monitoring in hadrontherapy with in-beam PET: A patient study

被引:30
作者
Fiorina, E. [1 ]
Ferrero, V. [1 ,2 ]
Pennazio, F. [1 ]
Baroni, G. [3 ,4 ]
Battistoni, G. [5 ]
Belcari, N. [6 ,7 ]
Cerello, P. [1 ]
Camarlinghi, N. [6 ,7 ]
Ciocca, M. [4 ]
Del Guerra, A. [6 ,7 ]
Donetti, M. [4 ]
Ferrari, A. [8 ]
Giordanengo, S. [1 ]
Giraudo, G. [1 ]
Mairani, A. [4 ]
Morrocchi, M. [6 ,7 ]
Peroni, C. [1 ,2 ]
Rivetti, A. [1 ]
Rolo, M. D. Da Rocha [1 ]
Rossi, S. [4 ]
Rosso, V. [6 ,7 ]
Sala, P. [5 ]
Sportelli, G. [6 ,7 ]
Tampellini, S. [4 ]
Valvo, F. [4 ]
Wheadon, R. [1 ]
Bisogni, M. G. [6 ,7 ]
机构
[1] Ist Nazl Fis Nucl, Sez Torino, Via Giuria 1, I-10125 Turin, Italy
[2] Univ Torino, Dipartimento Fis, Via Giuria 1, I-10125 Turin, Italy
[3] Politecn Milan, Piazza L Vinci Da 32, Milan, Italy
[4] Fdn CNAO, Ctr Nazl Adroterapia Oncol, Str Campeggi 53, I-27100 Pavia, Italy
[5] Ist Nazl Fis Nucl, Sez Milano, Via Celoria 16, I-20133 Milan, Italy
[6] Univ Pisa, Dipartimento Fis, Lungarno A Pacinotti 43, I-56126 Pisa, Italy
[7] Ist Nazl Fis Nucl, Sez Pisa, Largo B Pontecorvo 3, I-56127 Pisa, Italy
[8] CERN, CH-1211 Geneva 23, Switzerland
来源
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS | 2018年 / 51卷
关键词
Hadrontherapy; In-beam PET; Range monitoring; Monte Carlo simulation; POSITRON-EMISSION-TOMOGRAPHY; RANGE VERIFICATION; PROTON THERAPY; FLUKA CODE; SYSTEM; IMPLEMENTATION; UNCERTAINTIES;
D O I
10.1016/j.ejmp.2018.05.002
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Hadrontherapy is a method for treating cancer with very targeted dose distributions and enhanced radiobiological effects. To fully exploit these advantages, in vivo range monitoring systems are required. These devices measure, preferably during the treatment, the secondary radiation generated by the beam-tissue interactions. However, since correlation of the secondary radiation distribution with the dose is not straightforward, Monte Carlo (MC) simulations are very important for treatment quality assessment. The INSIDE project constructed an in-beam PET scanner to detect signals generated by the positron-emitting isotopes resulting from projectile-target fragmentation. In addition, a FLUKA-based simulation tool was developed to predict the corresponding reference PET images using a detailed scanner model. The INSIDE in-beam PET was used to monitor two consecutive proton treatment sessions on a patient at the Italian Center for Oncological Hadrontherapy (CNAO). The reconstructed PET images were updated every 10 s providing a near real-time quality assessment. By half-way through the treatment, the statistics of the measured PET images were already significant enough to be compared with the simulations with average differences in the activity range less than 2.5mm along the beam direction. Without taking into account any preferential direction, differences within 1mm were found. In this paper, the INSIDE MC simulation tool is described and the results of the first in vivo agreement evaluation are reported. These results have justified a clinical trial, in which the MC simulation tool will be used on a daily basis to study the compliance tolerances between the measured and simulated PET images.
引用
收藏
页码:71 / 80
页数:10
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