Cargo delivery on demand from photodegradable MOF nano-cages

被引：43
作者：
Epley, Charity C.
Roth, Kristina L.
Lin, Shaoyang
Ahrenholtz, Spencer R.
Grove, Tijana Z.
Morris, Amanda J. [1 ]
机构：
[1] Virginia Tech, Dept Chem, Blacksburg, VA 24061 USA
来源：
DALTON TRANSACTIONS | 2017年 / 46卷 / 15期
关键词：
METAL-ORGANIC-FRAMEWORK; THERMALLY RESPONSIVE POLYMERS; TARGETED DRUG-DELIVERY; CONTROLLED-RELEASE; PHOTODYNAMIC THERAPY; TRIGGERED RELEASE; CARBON-DIOXIDE; LIGHT; NANOPARTICLES; NANOCARRIERS;
D O I：
10.1039/c6dt04787d
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
We report the photo-induced degradation of and cargo release from a nanoscale metal-organic framework (nMOF) incorporating photo-isomerizable 4,4'-azobenzenedicarboxylate (AZB) linkers. The structure matches a UiO-type framework where 12 4,4'-azobenzenedicarboxylate moieties are connected to a Zr6O4(OH)(4) cluster, referred to as UiO-AZB. Due to the incorporation of photo-isomerizable struts, the degradation of UiO-AZB is accelerated by irradiation with white light (1.3 +/- 0.1% h(-1) under dark conditions vs. 8.4 +/- 0.4% h(-1) when irradiated). Additionally, we show slow release of Nile Red (NR) which is triggered by irradiation (0.04 +/- 0.01% h(-1) under dark conditions vs. 0.36 +/- 0.02% h(-1) when irradiated).
引用
收藏
页码：4917 / 4922
页数：6
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