Diagnostic value of blast cell immunophenotyping in adult acute myeloid leukemias

被引：0
作者：
Loginsky, VO
Vygovska, YI
Maslyak, ZV
Cymbaliuk, IP
Mazurok, AA
Karol, YS
机构：
来源：
EXPERIMENTAL ONCOLOGY | 1996年 / 18卷 / 02期
关键词：
leukemia; immunophenotyping; FAB-classification;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The expression of myeloid- and lymphoid-associated cell surface antigens was determined on the blast cells from 27 adult patients with acute myeloid leukemias (AML) classified according to the FAB system. A panel of 18 monoclonal antibodies (MoAb) was tested in indirect immunofluorescence. Distinctive patterns of the markers expression reffering to morphologically and cytochemically defined FAB subgroups were established. The blast cells in FAB M1 and M2 were HLA-Dr(+), CD13(+), CD14(-) and distin-guished by CD34 and CD15 expression. In FAB M4 and M5 blasts constantly expressed HLA-Dr, CD14, seldom CD34. in M4 cases they were positive for CD13, CD15 and MoAb BCA-09. FAB M6 was char-acterized by reactivity with MoAb HAE9. Immu-nophenotyping is useful for recognition of myeloid lineage commitment and particularly in determina-tion of maturation level of the malignant cells in AML.
引用
收藏
页码：146 / 151
页数：6
相关论文
共 50 条
[21]   Clofarabine in adult acute leukemias: Clinical success and pharmacokinetics [J].
Cooper, T ;
Kantarjian, H ;
Plunkett, W ;
Gandhi, V .
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2004, 23 (8-9) :1417-1423
[22]   Quantitative assessment of informative immunophenotypic markers increases the diagnostic value of immunophenotyping in mature CD5-positive B-cell neoplasms [J].
Starostka, David ;
Kriegova, Eva ;
Kudelka, Milos ;
Mikula, Peter ;
Zehnalova, Sarka ;
Radvansky, Martin ;
Papajik, Tomas ;
Kolacek, David ;
Chasakova, Katerina ;
Talianova, Hana .
CYTOMETRY PART B-CLINICAL CYTOMETRY, 2018, 94 (04) :576-587
[23]   Flow cytometry CD45 gating for immunophenotyping of acute myeloid leukemia [J].
Lacombe, F ;
Durrieu, F ;
Briais, A ;
Dumain, P ;
Belloc, F ;
Bascans, E ;
Reiffers, J ;
Boisseau, MR ;
Bernard, P .
LEUKEMIA, 1997, 11 (11) :1878-1886
[24]   Leukemia stem cell immunophenotyping tool for diagnostic, prognosis, and therapeutics [J].
de Rezende, Marina Mastelaro ;
Ferreira, Alice T. ;
Paredes-Gamero, Edgar J. .
JOURNAL OF CELLULAR PHYSIOLOGY, 2020, 235 (06) :4989-4998
[25]   Flow cytometry CD45 gating for immunophenotyping of acute myeloid leukemia [J].
F Lacombe ;
F Durrieu ;
A Briais ;
P Dumain ;
F Belloc ;
E Bascans ;
J Reiffers ;
MR Boisseau ;
Ph Bernard .
Leukemia, 1997, 11 :1878-1886
[26]   Health technology assessment-based approach to flow cytometric immunophenotyping of acute leukemias: a literature classification [J].
Gaipa, Giuseppe ;
Erba, Eugenio ;
Danova, Marco ;
Mazzini, Giuliano ;
Venditti, Adriano ;
Buldini, Barbara ;
Specchia, Giorgina ;
Maglia, Oscar ;
Kunkl, Annalisa ;
Ciriello, Maria Matilde ;
Arpinati, Mario ;
Mannelli, Francesco ;
Lanza, Francesco ;
Riccioni, Roberta ;
Pistotti, Vanna ;
Apolone, Giovanni .
TUMORI JOURNAL, 2020, 106 (03) :249-256
[27]   Image morphometry of acute leukemias - Comparison between lymphoid and myeloid subtypes [J].
Rajesh, L ;
Pattari, SK ;
Garewal, G ;
Dey, P ;
Srinivasan, R .
ANALYTICAL AND QUANTITATIVE CYTOLOGY AND HISTOLOGY, 2004, 26 (01) :57-60
[28]   The Effect of the Chernobyl Disaster on the Occurrence of Adult Acute Leukemias in Turkey [J].
Ozatli, Duezguen ;
Goeker, Hakan ;
Buyuhasik, Yahya ;
Sayinalp, Nilguen ;
Haznedaroglu, Ibrahim C. ;
Ozcebe, Osman I. .
TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, 2009, 29 (02) :388-394
[29]   Clinicopathologic, immunophenotyping and cytogenetic analysis of Sweet syndrome in Egyptian patients with acute myeloid leukemia [J].
El-Khalawany, Mohamed ;
Aboeldahab, Soha ;
Mosbeh, Al-Sadat ;
Thabet, Aida .
PATHOLOGY RESEARCH AND PRACTICE, 2017, 213 (02) :143-153
[30]   EFFECT OF HEMATOPOIETIC GROWTH-FACTORS ON THE PROLIFERATION OF ACUTE MYELOID AND LYMPHOID LEUKEMIAS [J].
AGLIETTA, M ;
DEFELICE, L ;
STACCHINI, A ;
SANAVIO, F ;
SEVERINO, A ;
SIMONE, F ;
PIACIBELLO, W ;
MANDELLI, F .
LEUKEMIA & LYMPHOMA, 1990, 2 (3-4) :207-214
12345