Amphidinolide T, novel 19-membered macrolide from marine dinoflagellate Amphidinium sp.

被引：59
作者：
Tsuda, M [1 ]
Endo, T [1 ]
Kobayashi, J [1 ]
机构：
[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2000年 / 65卷 / 05期
关键词：
D O I：
10.1021/jo991393r
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel 19-membered macrolide, amphidinolide T (1), has been isolated from a marine dinoflagellate Amphidinium sp., and the structure was elucidated on the basis of spectroscopic data. Relative stereochemistry at C-7, C-8, and C-10 was deduced from the NOESY correlations, while absolute configurations at C-2, C-13, C-14, and C-18 were assigned on the basis of NMR data of the MTPA esters of 1 and those of degradation products of 1.
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页码：1349 / 1352
页数：4
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