The antiperforation performance of protective structures has always been the focus of research in the field of military protection engineering. Because the explicit dynamic finite-element software LS-DYNA is suitable for the simulation of nonlinear and large deformation dynamic processes, it is used in this numerical investigation. The numerical results not only show the perforation process well, but the good agreement with the experiment also confirms the correctness of the numerical results. On the basis of numerical verification, a numerical investigation was carried out on the influence of the impact point, reinforcement ratio, and reinforcement arrangement on the antiperforation performance. The research results show that: (1) due to the discontinuous distribution of the reinforcement and the boundary, the position of the impact point may cause uncertainty in the protection effect, and numerical simulation can help us evaluate this uncertainty; (2) with the same reinforcement ratio, densifying reinforcement is a better method than thickening reinforcement in dealing with the uncertainty of the impact point, so it is more effective; and (3) the reinforcement arrangement has a great influence on the antiperforation performance. With the same amount of material, numerical optimization of the spatial arrangement of reinforcement can effectively improve the protection effect.