Bioactive Bromotyrosine-Derived Alkaloids from the Polynesian Sponge Suberea ianthelliformis

被引：16

作者：

El-Demerdash, Amr ^{[1
,2
]}

Moriou, Celine ^{[1
]}

Toullec, Jordan ^{[3
]}

Besson, Marc ^{[4
,5
]}

Soulet, Stephanie ^{[6
]}

Schmitt, Nelly ^{[6
]}

Petek, Sylvain ^{[3
]}

Lecchini, David ^{[4
]}

Debitus, Cecile ^{[3
]}

Al-Mourabit, Ali ^{[1
]}

机构：

[1] Univ Paris Saclay, Univ Paris Sud, CNRS, UPR 2301,Inst Chim Subst Nat, 1 Ave Terrasse, F-91198 Gif Sur Yvette, France

[2] Mansoura Univ, Div Organ Chem, Dept Chem, Fac Sci, Mansoura 35516, Egypt

[3] UBO, IFREMER, IUEM, LEMAR,IRD,CNRS, F-29280 Plouzane, France

[4] PSL Res Univ, CNRS, CRIOBE, EPHE,UPVD, F-98729 Moorea, French Polynesi, France

[5] Univ Pierre & Marie Curie Paris, Observ Oceanol Banyuls Sur Mer, F-66650 Banyuls Sur Mer, France

[6] UPF, EIO, ILM, IFREMER,IRD, F-98702 Tahiti, French Polynesi, France

来源：

MARINE DRUGS | 2018年 / 16卷 / 05期

关键词：

brominated tyrosine alkaloids; Suberea ianthelliformis; cytotoxicity; acetylcholinesterase inhibition; BROMINATED METABOLITES; ANTIBACTERIAL; ACETYLCHOLINESTERASE; APLYZANZINE; DERIVATIVES; INHIBITORS; TOXIN;

D O I：

10.3390/md16050146

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Herein, we describe the isolation and spectroscopic identification of eight new tetrabrominated tyrosine alkaloids 2-9 from the Polynesian sponge Suberea ianthelliformis, along with known major compound psammaplysene D (1), N,N-dimethyldibromotyramine, 5-hydroxy xanthenuric acid, and xanthenuric acid. Cytotoxicity and acetylcholinesterase inhibition activities were evaluated for some of the isolated metabolites. They exhibited moderate antiproliferative activity against KB cancer cell lines, but psammaplysene D (1) displayed substantial cytotoxicity as well as acetylcholinesterase inhibition with IC50 values of 0.7 M and 1.3 M, respectively.

引用

页数：16

共 43 条

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Limbadri, Salendra
Luo, Xiaowei
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Wang, Junfeng
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[J]. MOLECULES, 2018, 23 (09):
[42] Bioactive 2(1H)-Pyrazinones and Diketopiperazine Alkaloids from a Tunicate-Derived Actinomycete Streptomyces sp.
Shaala, Lamiaa A.
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Badr, Jihan M.
Harakeh, Steve M.
[J]. MOLECULES, 2016, 21 (09):
[43] Production and purification of a bioactive substance against multi-drug resistant human pathogens from the marine-sponge-derived Salinispora sp.
Satyendra Singh
Pritesh Prasad
Ramesh Subramani
William Aalbersberg
[J]. Asian Pacific Journal of Tropical Biomedicine, 2014, (10) : 825 - 831

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