Intrahepatic cholestasis of pregnancy

被引：419
作者：
Geenes, Victoria [1 ]
Williamson, Catherine [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Maternal & Fetal Dis Grp, Inst Reprod & Dev Biol, Div Surg Oncol Reprod Biol & Anaesthet,Fac Med, London W12 0NN, England
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2009年 / 15卷 / 17期
关键词：
Cholestasis; Pregnancy; Pruritus; Bile acid; SERUM BILE-ACIDS; SALT EXPORT PUMP; ADENOSYL-L-METHIONINE; LIVER-FUNCTION TESTS; INTRA-HEPATIC CHOLESTASIS; GLUTATHIONE-S-TRANSFERASE; ETHYNYLESTRADIOL-INDUCED IMPAIRMENT; PHOSPHOLIPID TRANSPORTER ABCB4; RESPIRATORY-DISTRESS-SYNDROME; C VIRUS-INFECTION;
D O I：
10.3748/wjg.15.2049
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder characterized by maternal pruritus in the third trimester, raised serum bile acids and increased rates of adverse fetal outcomes. The etiology of ICP is complex and not fully understood, but it is likely to result from the cholestatic effects of reproductive hormones and their metabolites in genetically susceptible women. Equally unclear are the mechanisms by which the fetal complications occur. This article reviews the epidemiology, clinical features, diagnosis, etiology and management of ICR (C) 2009 The WJG Press and Baishideng. All rights reserved.
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页码：2049 / 2066
页数：18
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