Providing both autologous and allogeneic hematopoietic stem cell transplants (HSCT) may have a stronger impact on the outcome of autologous HSCT in adult patients than activity levels or implementation of JACIE at Belgian transplant centres

被引：2

作者：

Poirel, Helene A. ^{[1
]}

Vanspauwen, Marijke ^{[1
]}

Macq, Gilles ^{[1
]}

De Geyndt, Anke ^{[1
]}

Maertens, Johan ^{[2
]}

Willems, Evelyne ^{[3
]}

Selleslag, Dominik ^{[4
]}

Poire, Xavier ^{[5
]}

Theunissen, Koen ^{[6
]}

Graux, Carlos ^{[7
]}

Kerre, Tessa ^{[8
,9
]}

Zachee, Pierre ^{[10
,11
]}

Meuleman, Nathalie ^{[12
]}

De Becker, Ann ^{[13
]}

Verlinden, Anke ^{[14
]}

Van Obbergh, Florence ^{[15
]}

Schuermans, Christine ^{[16
]}

De Wilde, Virginie ^{[17
]}

Jaspers, Aurelie ^{[18
]}

Pranger, Delphine ^{[19
]}

Deeren, Dries ^{[20
]}

Van Riet, Ivan ^{[13
,21
]}

Vaes, Evelien ^{[1
]}

Beguin, Yves ^{[3
,9
,11
,18
]}

机构：

[1] Belgian Canc Registry, Brussels, Belgium

[2] UZ Gasthuisberg Leuven, Leuven, Belgium

[3] CHU Liege, Liege, Belgium

[4] AZ Sint Jan Brugge Oostende, Brugge, Belgium

[5] UCL St Luc, Brussels, Belgium

[6] Jessa Ziekenhuis, Hasselt, Belgium

[7] CHU UCL Namur Godinne site, Yvoir, Belgium

[8] UZ Gent, Ghent, Belgium

[9] Belgian Hematol Soc Transplant Comm, Brussels, Belgium

[10] ZNA Antwerpen, Antwerp, Belgium

[11] Belgian Transplant Registry, Brussels, Belgium

[12] Inst Jules Bordet, Brussels, Belgium

[13] UZ Brussel, Brussels, Belgium

[14] Univ Antwerp Hosp, Edegem, Belgium

[15] Hop Jolimont, La Louviere, Belgium

[16] GZA Sint Augustinus, Antwerp, Belgium

[17] Erasmus Brussel, Brussels, Belgium

[18] CHR Citadelle, Liege, Belgium

[19] Grand Hop Charleroi, Charleroi, Belgium

[20] AZ Delta, Roeselare, Belgium

[21] JACIE Comm, Belgian Hematol Soc, Brussels, Belgium

来源：

BONE MARROW TRANSPLANTATION | 2019年 / 54卷 / 09期

关键词：

BONE-MARROW-TRANSPLANTATION; QUALITY MANAGEMENT-SYSTEM; EUROPEAN-SOCIETY; BLOOD; LEUKEMIA; ECONOMICS; MODELS; CARE; AGE;

D O I：

10.1038/s41409-019-0458-8

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

While performance since the introduction of the JACIE quality management system has been shown to be improved for allogeneic hematopoietic stem cell transplants (HSCT), impact on autologous-HSCT remains unclear in Europe. Our study on 2697 autologous-HSCT performed in adults in 17 Belgian centres (2007-2013) aims at comparing the adjusted 1 and 3-yr survival between the different centres & investigating the impact of 3 centre-related factors on performance (time between JACIE accreditation achievement by the centre and the considered transplant, centre activity volume and type of HSCT performed by centres: exclusively autologous vs both autologous & allogeneic). We showed a relatively homogeneous performance between Belgian centres before national completeness of JACIE implementation. The 3 centre-related factors had a significant impact on the 1-yr survival, while activity volume and type of HSCT impacted the 3-yr survival of autologous-HSCT patients in univariable analyses. Only activity volume (impact on 1-yr survival only) and type of HSCT (impact on 1 and 3-yr survivals) remained significant in multivariable analysis. This is explained by the strong relationship between these 3 variables. An extended transplantation experience, i.e., performing both auto & allo-HSCT, appears to be a newly informative quality indicator potentially conveying a multitude of underlying complex factors.

引用

页码：1434 / 1442

页数：9

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