Efficient synthesis of substituted 2-(4H-1,3-benzoxazin-2-yl) phenols via a pseudo three-component reaction

被引：1

作者：

Wang, Ting ^{[1
]}

Dai, Chenlu ^{[1
]}

Qing, Xushun ^{[1
]}

Wang, Cunde ^{[1
]}

机构：

[1] Yangzhou Univ, Sch Chem & Chem Engn, 180 Siwangting St, Yangzhou 225002, Jiangsu, Peoples R China

来源：

JOURNAL OF CHEMICAL RESEARCH | 2018年 / 03期

基金：

中国国家自然科学基金;

关键词：

4H-1,3-benzoxazine; pseudo three-component reaction; substituted; 2-hydroxybenzaldehyde; oxazine; annulation reaction; DNA-PK; INHIBITORS; PI3K; ALDEHYDES; DESIGN; POTENT;

D O I：

10.3184/174751918X15199181776822

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient pseudo three-component reaction between substituted 2-hydroxybenzaldehydes and ammonium acetate for the preparation of substituted 2-(4H-1,3-benzoxazin-2-yl) phenols in moderate to good yields (70-80%) was developed. The structure of a typical product was confirmed by X-ray crystallography.

引用

收藏

页码：121 / 124

页数：4

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