Alkylation of 4,5-dichloropyridazin-6-one with alpha,omega-dibromoalkanes 4,5-dichloro-1-(omega-bromoalkyl)pyridazin-6-ones

被引：15

作者：

Kim, SK ^{[1
]}

Cho, SD ^{[1
]}

Kweon, DH ^{[1
]}

Yoon, YJ ^{[1
]}

Kim, JH ^{[1
]}

Heo, JN ^{[1
]}

机构：

[1] AGROCHEM LABS,HANWHA GRP RES & ENGN CTR,TAEJON 305345,SOUTH KOREA

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1997年 / 34卷 / 01期

关键词：

D O I：

10.1002/jhet.5570340131

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Alkylations of 4,5-dichloropyridazin-6-one (1) with dibromoalkanes 2 or 3 in the presence of potassium carbonate or tetrabutylammonium bromide/potassium hydroxide were investigated under restricted condition. Reactions of 1 with 2 or 3, except for 2b and 3b, in the presence of potassium carbonate or tetrabutylammonium bromide/potassium hydroxide gave only the N-alkylation products 3 and/or 4. Alkylation of 1 with 2b or 3b in the presence of potassium carbonate yielded the N-alkylation products 3b and/or 4b and the O-alkylation product 5 as the main product, whereas treatment of 1 with 2b or 3b in the presence of tetrabutylammonium bromide/potassium hydroxide afforded selectively the N-alkylation products 3b and/or 4b.

引用

页码：209 / 214

页数：6

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