Quantitative structure-activity relationship studies on some acyclouridine derivatives acting as anti-HIV-1 drugs

被引：15

作者：

Garg, R

Kurup, A

Gupta, SP

机构：

[1] BIRLA INST TECHNOL & SCI,DEPT CHEM,PILANI 333031,RAJASTHAN,INDIA

[2] BIRLA INST TECHNOL & SCI,DEPT PHARM,PILANI 333031,RAJASTHAN,INDIA

来源：

QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS | 1997年 / 16卷 / 01期

关键词：

quantitative structure-activity relationship; HIV-1; inhibitors; HEPT derivatives;

D O I：

10.1002/qsar.19970160104

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The anti-HIV-1 activity of some derivatives of 1-[2-hydroxyethoxy]-6-(phenylthio)thymine(HEPT) is analyzed in relation to their physicochemical and molecular properties. The activities of the compounds are found to be significantly correlated with hydrophobic constant 71 and the van der Waals volume V-w. The results are found to be useful in discussing the mechanism of drug-receptor interaction.

引用

页码：20 / 24

页数：5

共 13 条

[11] STRUCTURE-ACTIVITY-RELATIONSHIPS OF 1-[(2-HYDROXYETHOXY)METHYL]-6-(PHENYLTHIO)THYMINE ANALOGS - EFFECT OF SUBSTITUTIONS AT THE C-6 PHENYL RING AND AT THE C-5 POSITION ON ANTI-HIV-1 ACTIVITY [J].