One-Pot Asymmetric Synthesis of Quaternary Pyrroloindolones through a Multicatalytic N-Allylation/Hydroacylation Sequence

被引：55

作者：

Lu, Hong ^{[1
]}

Lin, Jun-Bing ^{[1
]}

Liu, Jin-Yu ^{[1
]}

Xu, Peng-Fei ^{[1
]}

机构：

[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2014年 / 20卷 / 37期

关键词：

asymmetric catalysis; carbenes; hydroacylation; indoles; multicatalysis; BAYLIS-HILLMAN CARBONATES; ANTI-MICHAEL ADDITION; INTERMOLECULAR STETTER REACTION; HETEROCYCLIC CARBENE; CASCADE REACTION; ENANTIOSELECTIVE SYNTHESIS; ALLYLIC ALKYLATION; CATALYZED HYDROACYLATION; REGIOSPECIFIC APPROACH; ALKYNE HYDROACYLATION;

D O I：

10.1002/chem.201402947

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An intramolecular, quaternary carbon center forming hydroacylation of alpha-substituted acrylates has been discovered. This interesting transformation can be readily incorporated into a multicatalytic tandem process enabled by a combination of nucleophilic tertiary amine and N-heterocyclic carbene catalysis. With no additional stoichiometric base required, this transformation affords the quaternary pyrroloindolones with high levels of enantioselectivity.

引用

页码：11659 / 11663

页数：5

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