One-Pot Asymmetric Synthesis of Quaternary Pyrroloindolones through a Multicatalytic N-Allylation/Hydroacylation Sequence

被引：55
|
作者：
Lu, Hong [1 ]
Lin, Jun-Bing [1 ]
Liu, Jin-Yu [1 ]
Xu, Peng-Fei [1 ]
机构：
[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2014年 / 20卷 / 37期
关键词：
asymmetric catalysis; carbenes; hydroacylation; indoles; multicatalysis; BAYLIS-HILLMAN CARBONATES; ANTI-MICHAEL ADDITION; INTERMOLECULAR STETTER REACTION; HETEROCYCLIC CARBENE; CASCADE REACTION; ENANTIOSELECTIVE SYNTHESIS; ALLYLIC ALKYLATION; CATALYZED HYDROACYLATION; REGIOSPECIFIC APPROACH; ALKYNE HYDROACYLATION;
D O I：
10.1002/chem.201402947
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An intramolecular, quaternary carbon center forming hydroacylation of alpha-substituted acrylates has been discovered. This interesting transformation can be readily incorporated into a multicatalytic tandem process enabled by a combination of nucleophilic tertiary amine and N-heterocyclic carbene catalysis. With no additional stoichiometric base required, this transformation affords the quaternary pyrroloindolones with high levels of enantioselectivity.
引用
收藏
页码：11659 / 11663
页数：5
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