Micropreparative Isolation of Cu(II) Complexes of Isoniazid and Ethambutol and Determination of their Structures

被引：4
作者：
Flieger, Jolanta [1 ]
Paneth, Piotr [2 ]
Gielzak-Kocwin, Krystyna [3 ]
Tatarczak, Malgorzata [1 ]
机构：
[1] Med Univ Lublin, Dept Inorgan & Analyt Chem, PL-20081 Lublin, Poland
[2] Tech Univ Lodz, Inst Appl Radiat Chem, PL-90924 Lodz, Poland
[3] Jan Dlugosz Acad, Inst Chem, PL-42201 Czestochowa, Poland
来源：
JPC-JOURNAL OF PLANAR CHROMATOGRAPHY-MODERN TLC | 2009年 / 22卷 / 02期
关键词：
Micropreparative TLC; Cu(II) complexes; Ioniazid; Pyrazinamide; Ethambutol; p-Aminosalicylic acid; EPR analysis; Molecular modeling; MYCOBACTERIUM-TUBERCULOSIS; COPPER; THERAPY; ZINC; APPROXIMATION; EXCHANGE; DENSITY;
D O I：
10.1556/JPC.22.2009.2.2
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
We report the chromatographic behavior of the antitubercular drugs isoniazid (INH), pyrazinamide (PYR), ethambutol (ETB), and p-aminosalicylic acid (PAS) in reversed-phase TLC with organic aqueous mobile phases modified with Cu(II) chloride. The spectra of the free ligands and complexes formed during chromatography were measured dnsitometrically by use of a scanner equipped with a diode-array detector and compared in the range 200-700 nm. The complexes of Cu(II) with isoniazid and ethambutol were isolated on a micropreparative scale. The structures of the TNH-Cu and EMB-Cu complexes were analyzed by electron paramagnetic resonance (EPR) spectroscopy and illustrated graphically by molecular modeling using GaussView software.
引用
收藏
页码：83 / 88
页数：6
相关论文
共 26 条
123