Potential of boron neutron capture therapy (BNCT) for malignant peripheral nerve sheath tumors (MPNST)

被引：6

作者：

Fujimoto, Takuya ^{[1
]}

Andoh, Tooru ^{[2
,3
]}

Sudo, Tamotsu ^{[4
]}

Fujita, Ikuo ^{[1
]}

Fukase, Naomasa ^{[1
]}

Takeuchi, Tamotsu ^{[5
]}

Sonobe, Hiroshi ^{[6
]}

Inoue, Masayoshi ^{[7
]}

Hirose, Tkanori ^{[8
]}

Sakuma, Toshiko ^{[8
]}

Moritake, Hiroshi ^{[9
]}

Sugimoto, Tohru ^{[10
]}

Kawamoto, Teruya ^{[11
]}

Fukumori, Yoshinobu ^{[2
,3
]}

Yamamoto, Satomi ^{[12
]}

Atagi, Shinji ^{[13
]}

Sakurai, Yoshinori ^{[14
]}

Kurosaka, Masahiro ^{[11
]}

Ono, Koji ^{[15
]}

Ichikawa, Hideki ^{[2
,3
]}

Suzuki, Minoru ^{[15
]}

机构：

[1] Hyogo Canc Ctr, Dept Orthopaed Surg, Akashi, Hyogo 6730021, Japan

[2] Kobe Gakuin Univ, Fac Pharmaceut Sci, Kobe, Hyogo 6508586, Japan

[3] Kobe Gakuin Univ, Cooperat Res Ctr Life Sci, Kobe, Hyogo 6508586, Japan

[4] Hyogo Canc Ctr, Sect Translat Res, Akashi, Hyogo 6730021, Japan

[5] Gifu Univ, Grad Sch Med, Dept Immunopathol, Gifu 5011194, Japan

[6] Chugoku Cent Hosp, Dept Clin Lab, Fukuyama, Hiroshima 7200001, Japan

[7] Osaka Univ, Grad Sch Med, Dept Gen Thorac Surg, Suita, Osaka 5650871, Japan

[8] Hyogo Canc Ctr, Dept Diagnost Pathol, Akashi, Hyogo 6730021, Japan

[9] Miyazaki Univ, Div Pediat, Miyazaki 8891692, Japan

[10] Saiseikai Shiga Hosp, Dept Pediat, Ritto 5203046, Japan

[11] Kobe Univ, Grad Sch Med, Dept Orthopaed Surg, Kobe, Hyogo 6500017, Japan

[12] Univ Kansas, Ctr Canc, Kansas City, KS 66160 USA

[13] Kinki Chuo Chest Med Ctr, Dept Internal Med, Sakai, Osaka 5918025, Japan

[14] Kyoto Univ, Inst Res Reactor, Div Radiat Life Sci, Kyoto 5900494, Japan

[15] Kyoto Univ, Inst Res Reactor, Particle Radiat Oncol Res Ctr, Kyoto 5900494, Japan

来源：

APPLIED RADIATION AND ISOTOPES | 2015年 / 106卷

基金：

日本学术振兴会;

关键词：

Malignant peripheral nerve sheath tumors (MPNST); NF1; Clear cell sarcoma; HS-Sch-2; Boron neutron capture therapy (BNCT); p-Borono-(L)-phenylalanine; CLEAR-CELL SARCOMA; VONRECKLINGHAUSEN NEUROFIBROMATOSIS; SOFT PARTS; MELANOMA; LINE; CCS;

D O I：

10.1016/j.apradiso.2015.07.059

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Malignant peripheral nerve sheath tumors (MPNST) are relatively rare neoplasms with poor prognosis. At present there is no effective treatment for MPNST other than surgical resection. Nonetheless, the antitumor effect of boron neutron capture therapy (BNCT) was recently demonstrated in two patients with MPNST. Subsequently, tumor-bearing nude mice subcutaneously transplanted with a human MPNST cell line were injected with p-borono-(L)-phenylalanine ((L)-BPA) and subjected to BNCT. Pathological studies then revealed that the MPNST cells were selectively destroyed by BNCT. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：220 / 225

页数：6

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