Modeling of drug release from swellable polymers

被引：275

作者：

Brazel, CS ^{[1
]}

Peppas, NA ^{[1
]}

机构：

[1] Purdue Univ, Sch Chem Engn, Biomat & Drug Delivery Labs, W Lafayette, IN 47907 USA

来源：

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2000年 / 49卷 / 01期

基金：

美国国家科学基金会;

关键词：

relaxation; swellable systems; drug release; poly(vinyl alcohol); poly(2-hydroxyethyl methacrylate);

D O I：

10.1016/S0939-6411(99)00058-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The water swelling and drug diffusion from initially hydrophilic, glassy polymer matrices were modeled using concentration-dependent diffusion equations for water and drug. The transport equation for water incorporated a relaxation-dependent mechanism. These equations were solved with an appropriate boundary condition incorporating a relaxation-dependent Deborah number. Experimental results from drug release from PVA and PHEMA samples were used to determine the validity of the model. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：47 / 58

页数：12

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