Nor-lignans and steroidal saponins from Asparagus gobicus

被引：28

作者：

Yang, CX ^{[1
]}

Huang, SS ^{[1
]}

Yang, XP ^{[1
]}

Jia, ZJ ^{[1
]}

机构：

[1] Lanzhou Univ, Coll Chem & Chem Engn, Natl Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China

来源：

PLANTA MEDICA | 2004年 / 70卷 / 05期

关键词：

Asparagus gobicus; Asparagaceae; nor-lignans; steroidal saponins; cytotoxic activity;

D O I：

10.1055/s-2004-818974

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

From the roots of Asparagus gobicus, four new nor-lignans, 3-methoxynyasin, iso-agatharesinol, gobicusins A, B and one new steroidal saponin, 3-O-[beta-D-xylopyranosyl(1-4)-beta-D-glicopyranosyl(1 -2)-beta-D-glucopyranosyl]-(25S)-5beta-spirostan-3beta-ol (11) were isolated, together with twelve known compounds. The structures of the new compounds were established by spectroscopic methods including 2D-NMR techniques (H-1-H-1 COSY, HMBC, HMQC) and chemical transformations. Nyasol (5) and 11 exhibited remarkable in vitro cytotoxic activity against cultured HO-8910 (human ovarian carcinoma) and Bel-7402 (human hepatoma) cells With IC50 vales of 30.6 and 29.4 muM, 5.2 and 5.2 muM, respectively.

引用

页码：446 / 451

页数：6

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