Nor-lignans and steroidal saponins from Asparagus gobicus

被引：27
|
作者：
Yang, CX [1 ]
Huang, SS [1 ]
Yang, XP [1 ]
Jia, ZJ [1 ]
机构：
[1] Lanzhou Univ, Coll Chem & Chem Engn, Natl Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China
来源：
PLANTA MEDICA | 2004年 / 70卷 / 05期
关键词：
Asparagus gobicus; Asparagaceae; nor-lignans; steroidal saponins; cytotoxic activity;
D O I：
10.1055/s-2004-818974
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
From the roots of Asparagus gobicus, four new nor-lignans, 3-methoxynyasin, iso-agatharesinol, gobicusins A, B and one new steroidal saponin, 3-O-[beta-D-xylopyranosyl(1-4)-beta-D-glicopyranosyl(1 -2)-beta-D-glucopyranosyl]-(25S)-5beta-spirostan-3beta-ol (11) were isolated, together with twelve known compounds. The structures of the new compounds were established by spectroscopic methods including 2D-NMR techniques (H-1-H-1 COSY, HMBC, HMQC) and chemical transformations. Nyasol (5) and 11 exhibited remarkable in vitro cytotoxic activity against cultured HO-8910 (human ovarian carcinoma) and Bel-7402 (human hepatoma) cells With IC50 vales of 30.6 and 29.4 muM, 5.2 and 5.2 muM, respectively.
引用
收藏
页码：446 / 451
页数：6
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