DNA-Based Chemical Reaction Networks

被引：11

作者：

Li, Fan ^{[1
,2
]}

Xiao, Mingshu ^{[1
]}

Pei, Hao ^{[1
]}

机构：

[1] East China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Sch Chem & Mol Engn, 500 Dongchuan Rd, Shanghai 200241, Peoples R China

[2] Shenzhen Univ, Guangdong Key Lab Biomed Measurements & Ultrasoun, Lab Evolutionary Theranost, Sch Biomed Engn,Hlth Sci Ctr, Nanhai Ave 3688, Guangzhou 518060, Guangdong, Peoples R China

来源：

CHEMBIOCHEM | 2019年 / 20卷 / 09期

基金：

美国国家科学基金会;

关键词：

biotechnology; chemical reaction networks; DNA; DNA recognition; strand-displacement reactions; ROLLING CIRCLE AMPLIFICATION; NUCLEIC-ACID NANOSTRUCTURES; STRAND-DISPLACEMENT; TARGETED TRANSPORT; RATIONAL DESIGN; IN-SITU; COMPUTATION; PLATFORM; CIRCUIT; PRINCIPLES;

D O I：

10.1002/cbic.201800721

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Motivated by complex molecular networks of biological organisms, which enable control of the temporal and spatial concentrations of molecules, the bottom-up development of artificial chemical reaction networks has received renewed interest from biochemists. Based on hybridization and strand-displacement reactions, DNA-based chemical reaction networks (D-CRNs) provide a promising method to describe and analyze (bio)chemical systems, depending on their high programmability and directionality. Herein, progress in the development of D-CRNs is discussed, and an overview of significant biochemistry applications based on D-CRNs reported in recent decades is provided. Furthermore, opportunities and future directions for research into D-CRNs in biochemistry are also discussed.

引用

页码：1105 / 1114

页数：10

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