Interleukin-1β as a mechanism for stress-induced startle suppression in females

被引：7
作者：
Beck, Kevin D.
Servatius, Richard J.
机构：
[1] Vet Affairs New Jersey Hlth Care Syst, Neurobehav Res Lab 129, E Orange, NJ 07019 USA
[2] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Neurosci, Newark, NJ 07103 USA
[3] Univ Med & Dent New Jersey, New Jersey Med Sch, Stress & Moticated Behav Inst, Newark, NJ 07103 USA
来源：
PSYCHOBIOLOGY OF POSTTRAUMATIC STRESS DISORDER: A DECADE OF PROGRESS | 2006年 / 1071卷
关键词：
sex differences; stress; cytokines; behavior;
D O I：
10.1196/annals.1364.058
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Startle measures were taken 2 h following a systemic injection of interleukin-1 beta (IL-1 beta) (3 mu g/kg) to intact or ovariectomy (OVX) female rats. Changes in startle responsivity (reduced startle magnitude) were evident in intact IL-1 beta-treated rats, despite no significant effects on startle sensitivity (number of elicited startles). No significant changes in startle sensitivity or responsivity were evident in IL-1 beta-treated OVX rats. These results are discussed as a possible mechanism for stress-induced suppression of startle responsivity seen in intact female rats.
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收藏
页码：534 / 537
页数：4
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