The Effect of Nonsurgical Periodontal Treatment on Serum and Gingival crevicular fluid markers in patients with atherosclerosis

被引:8
作者
Ertugrul, A. S. [1 ]
Bozoglan, A. [2 ]
Taspinar, M. [3 ]
机构
[1] Izmir Katip Celebi Univ, Dept Periodontol, Fac Dent, Izmir, Turkey
[2] Yuzuncu Yil Univ, Fac Dent, Dept Periodontol, Van, Turkey
[3] Yuzuncu Yil Univ, Fac Med, Dept Med Biol & Genet, Van, Turkey
关键词
Adrenomedullin; atherosclerosis; chemokine (C-C motif) ligand-28; chronic periodontitis; C-REACTIVE PROTEIN; ADRENOMEDULLIN; INFLAMMATION; HOMEOSTASIS; EXPRESSION; PEPTIDES; DISEASE; COHORT; ROLES;
D O I
10.4103/1119-3077.181369
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background and Aims: The aim of this study is to compare patients with atherosclerosis and chronic periodontitis and patients who are systemically healthy and chronic periodontitis using alteration of adrenomedullin (ADM), chemokine (C-C motif) ligand 28 (CCL-28), white blood cell levels, platelet levels, high-density lipoprotein, low-density lipoprotein, high-sensitivity C-reactive protein, creatinine, and fibrinogen. Materials and Methods: Totally, 40 patients were involved in study; a test group of 20 patients with atherosclerosis-chronic periodontitis and a control group of 20 patients who were nonatherosclerosis-chronic periodontitis. Nonsurgical periodontal treatment was offered to all patients, in whom systemic markers of atherosclerosis were measured in serum; ADM and CCL-28 biomarkers were measured in gingival crevicular fluid. Results: Systemic markers of atherosclerosis, ADM, and CCL-28 levels have changed significantly in the test group compared to the control group after nonsurgical periodontal treatment. Conclusions: Treatment of local inflammation and reduction of systemic inflammatory markers are believed to lower the diagnostic criteria for atherosclerosis as well. It is possible to conclude that nonsurgical periodontal treatment of chronic periodontitis, which is a risk factor for atherosclerosis, has a positive effect on the atherosclerosis prognosis.
引用
收藏
页码:361 / 368
页数:8
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