The effect of G-CSF on the composition of human bone marrow

被引：8
|
作者：
Tegg, EM [1 ]
Tuck, DM [1 ]
Lowenthal, RM [1 ]
Marsden, KA [1 ]
机构：
[1] Royal Hobart Hosp, Clin Haematol & Med Oncol Unit, Hobart, Tas 7001, Australia
来源：
CLINICAL AND LABORATORY HAEMATOLOGY | 1999年 / 21卷 / 04期
关键词：
bone marrow; G-CSF; morphology;
D O I：
10.1046/j.1365-2257.1999.00227.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The effects on bone marrow cellularity and morphology of 6 days' treatment with granulocyte colony-stimulating factor (G-CSF) in 35 patients were studied. Examination of trephine biopsies showed a highly significant increase in cellularity (P < 10(-13)). Assessment of aspirates revealed an increase in the myeloid to erythroid (M : E) ratio (P = 0.00006), the proportion of myeloid cells (P < 10(-8)), myelocytes (P = 0.00007), metamyelocytes (P = 0.04), band forms (P = 0.0005) and neutrophils (P = 0.02). This study presents a comprehensive analysis of the effects of six days' administration of G-CSF on human bone marrow.
引用
收藏
页码：265 / 270
页数：6
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