The effect of G-CSF on the composition of human bone marrow

被引：8

作者：

Tegg, EM ^{[1
]}

Tuck, DM ^{[1
]}

Lowenthal, RM ^{[1
]}

Marsden, KA ^{[1
]}

机构：

[1] Royal Hobart Hosp, Clin Haematol & Med Oncol Unit, Hobart, Tas 7001, Australia

来源：

CLINICAL AND LABORATORY HAEMATOLOGY | 1999年 / 21卷 / 04期

关键词：

bone marrow; G-CSF; morphology;

D O I：

10.1046/j.1365-2257.1999.00227.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effects on bone marrow cellularity and morphology of 6 days' treatment with granulocyte colony-stimulating factor (G-CSF) in 35 patients were studied. Examination of trephine biopsies showed a highly significant increase in cellularity (P < 10(-13)). Assessment of aspirates revealed an increase in the myeloid to erythroid (M : E) ratio (P = 0.00006), the proportion of myeloid cells (P < 10(-8)), myelocytes (P = 0.00007), metamyelocytes (P = 0.04), band forms (P = 0.0005) and neutrophils (P = 0.02). This study presents a comprehensive analysis of the effects of six days' administration of G-CSF on human bone marrow.

引用

页码：265 / 270

页数：6

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