The effect of G-CSF on the composition of human bone marrow

被引：8
作者：
Tegg, EM [1 ]
Tuck, DM [1 ]
Lowenthal, RM [1 ]
Marsden, KA [1 ]
机构：
[1] Royal Hobart Hosp, Clin Haematol & Med Oncol Unit, Hobart, Tas 7001, Australia
来源：
CLINICAL AND LABORATORY HAEMATOLOGY | 1999年 / 21卷 / 04期
关键词：
bone marrow; G-CSF; morphology;
D O I：
10.1046/j.1365-2257.1999.00227.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The effects on bone marrow cellularity and morphology of 6 days' treatment with granulocyte colony-stimulating factor (G-CSF) in 35 patients were studied. Examination of trephine biopsies showed a highly significant increase in cellularity (P < 10(-13)). Assessment of aspirates revealed an increase in the myeloid to erythroid (M : E) ratio (P = 0.00006), the proportion of myeloid cells (P < 10(-8)), myelocytes (P = 0.00007), metamyelocytes (P = 0.04), band forms (P = 0.0005) and neutrophils (P = 0.02). This study presents a comprehensive analysis of the effects of six days' administration of G-CSF on human bone marrow.
引用
收藏
页码：265 / 270
页数：6
相关论文
共 50 条
  • [1] FILGRASTIM (G-CSF) FOR ALLOGENEIC BONE MARROW TRANSPLANTATION
    T.Masaoka
    中华医学杂志(英文版), 1994, (10) : 21 - 22
  • [2] G-CSF promotes bone marrow cells to migrate into infarcted mice heart, and differentiate into cardiomyocytes
    Fukuhara, S
    Tomita, S
    Nakatani, T
    Ohtsu, Y
    Ishida, M
    Yutani, C
    Kitamura, S
    CELL TRANSPLANTATION, 2004, 13 (7-8) : 741 - 748
  • [3] THE EFFECT OF GM-CSF AND G-CSF ON HUMAN NEUTROPHIL FUNCTION
    BOBER, LA
    GRACE, MJ
    PUGLIESESIVO, C
    ROJASTRIANA, A
    WATERS, T
    SULLIVAN, LM
    NARULA, SK
    IMMUNOPHARMACOLOGY, 1995, 29 (02): : 111 - 119
  • [4] Etoposide with without G-CSF with busulfan and cyclophosphamide as conditioning for bone marrow transplantation
    Kanda, Y
    Akiyama, H
    Tanikawa, S
    Sakamaki, H
    Sasaki, T
    Takamoto, S
    Onozawa, Y
    AMERICAN JOURNAL OF HEMATOLOGY, 1996, 51 (04) : 265 - 268
  • [5] The evaluation of G-CSF for mobilization of autologous bone marrow stem cells in cirrhosis
    Wang Di
    Guo Xiao-Zhong
    Li Hong-Yu
    Shao Xiao-Dong
    Cui Zhong-Min
    Ren Li-Nan
    Zhao Jia-Jun
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2013, 28 : 831 - 831
  • [6] Effect of concomitant use of G-CSF and myelosuppressive chemotherapy on bone marrow and peripheral granulocytes in a mouse model
    Endo, Yuki
    Ishikawa, Takeshi
    Oka, Kaname
    Sakakida, Tomoki
    Matsumura, Shinya
    Mizushima, Katsura
    Doi, Toshifumi
    Okayama, Tetsuya
    Katada, Kazuhiro
    Kamada, Kazuhiro
    Uchiyama, Kazuhiko
    Takagi, Tomohisa
    Fujiwara, Hitoshi
    Konishi, Hideyuki
    Naito, Yuji
    Itoh, Yoshito
    MEDICAL ONCOLOGY, 2022, 39 (08)
  • [7] Effect of concomitant use of G-CSF and myelosuppressive chemotherapy on bone marrow and peripheral granulocytes in a mouse model
    Yuki Endo
    Takeshi Ishikawa
    Kaname Oka
    Tomoki Sakakida
    Shinya Matsumura
    Katsura Mizushima
    Toshifumi Doi
    Tetsuya Okayama
    Kazuhiro Katada
    Kazuhiro Kamada
    Kazuhiko Uchiyama
    Tomohisa Takagi
    Hitoshi Fujiwara
    Hideyuki Konishi
    Yuji Naito
    Yoshito Itoh
    Medical Oncology, 39
  • [8] Autologous transplantation of G-CSF mobilized bone marrow cells in a child with disseminated fibrosarcoma
    PM Hoogerbrugge
    RM Egeler
    Bone Marrow Transplantation, 1997, 20 : 613 - 614
  • [9] G-CSF AFTER AUTOLOGOUS BONE-MARROW TRANSPLANTATION FOR MALIGNANT DISEASES IN CHILDREN
    MADERO, L
    MUNOZ, A
    DEHEREDIA, AD
    MARTINEZ, A
    BADELL, I
    ESQUEMBRE, C
    RAMIREZ, M
    OTHEO, E
    OLIVE, A
    SASTRE, A
    PARDO, N
    CASTELL, V
    BONE MARROW TRANSPLANTATION, 1995, 15 (03) : 349 - 351
  • [10] G-CSF: From granulopoietic stimulant to bone marrow stem cell mobilizing agent
    Bendall, Linda J.
    Bradstock, Kenneth F.
    CYTOKINE & GROWTH FACTOR REVIEWS, 2014, 25 (04) : 355 - 367
12345