Soluble intercellular adhesion molecule-1 in primary biliary cirrhosis: Effect of ursodeoxycholic acid and immunosuppressive therapy

被引:0
|
作者
Lim, AG [1 ]
Wolfhagen, FHJ [1 ]
Verma, A [1 ]
vanBuuren, HR [1 ]
Jazrawi, RP [1 ]
Levy, JH [1 ]
Northfield, TC [1 ]
Schalm, SW [1 ]
机构
[1] ST GEORGE HOSP, SCH MED, DIV BIOCHEM MED, LONDON, ENGLAND
关键词
intercellular adhesion molecule-1; primary biliary cirrhosis; ursodeoxycholic acid; azathioprine; prednisone;
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Objectives: Soluble intercellular adhesion molecule-1 (sICAM-1) is thought to be released by a variety of cells at sites of inflammation, and their serum levels have been used as markers of inflammatory and immune activity. Our aim was to determine the effect of therapy with ursodeoxycholic acid alone and in combination with azathioprine and prednisone on serum sICAM-1 levels in primary biliary cirrhosis. Design/methods: Twenty-four patients with primary biliary cirrhosis and 17 healthy subjects were studied. Primary biliary cirrhosis patients received ursodeoxycholic acid for 12 months and were then randomized in a double-blind fashion to receive prednisone and azathioprine, or placebo in addition to ursodeoxycholic acid. Results: sICAM-1 levels were significantly higher in primary biliary cirrhosis patients than healthy subjects and fell by a median of 20% after 12 months' therapy with ursodeoxycholic acid (P<0.0004). Addition of azathioprine and prednisone to ursodeoxycholic acid resulted in a further reduction of sICAM-1 levels by a median of 25% (P < 0.01). Reductions in sICAM-1 were accompanied by improvement in liver function tests but not in the lymphocyte activation marker, soluble interleukin-2 receptor. Conclusion: sICAM-1 levels in primary biliary cirrhosis are reduced by ursodeoxycholic acid. Further reductions were achieved by adding prednisone and azathioprine. These reductions probably reflect an improvement in hepatobiliary excretion and a reduction in cellular production of sICAM-1.
引用
收藏
页码:155 / 161
页数:7
相关论文
共 50 条
  • [31] Moexipril for Treatment of Primary Biliary Cirrhosis in Patients with an Incomplete Response to Ursodeoxycholic Acid
    Phunchai Charatcharoenwitthaya
    Jayant A. Talwalkar
    Paul Angulo
    Andrea A. Gossard
    Jill C. Keach
    Janice L. Petz
    Roberta A. Jorgensen
    Keith D. Lindor
    Digestive Diseases and Sciences, 2010, 55 : 476 - 483
  • [32] DOES CHOLESTYRAMINE REDUCE THE EFFICACY OF URSODEOXYCHOLIC ACID IN PRIMARY BILIARY-CIRRHOSIS
    TAHA, AS
    ALLISON, MC
    MYARA, A
    TRIVIN, F
    DUNCAN, A
    RUSSELL, RI
    EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 1994, 6 (06) : 535 - 538
  • [33] Bezafibrate Treatment of Primary Biliary Cirrhosis Following Incomplete Response to Ursodeoxycholic Acid
    Hazzan, Rawi
    Tur-Kaspa, Ran
    JOURNAL OF CLINICAL GASTROENTEROLOGY, 2010, 44 (05) : 371 - 373
  • [34] Moexipril for Treatment of Primary Biliary Cirrhosis in Patients with an Incomplete Response to Ursodeoxycholic Acid
    Charatcharoenwitthaya, Phunchai
    Talwalkar, Jayant A.
    Angulo, Paul
    Gossard, Andrea A.
    Keach, Jill C.
    Petz, Janice L.
    Jorgensen, Roberta A.
    Lindor, Keith D.
    DIGESTIVE DISEASES AND SCIENCES, 2010, 55 (02) : 476 - 483
  • [35] (75)SEHCAT FRACTIONAL TURNOVER RATE IN PRIMARY BILIARY-CIRRHOSIS - EFFECT OF URSODEOXYCHOLIC ACID TREATMENT
    FRACCHIA, M
    PELLERITO, R
    FERRARIS, R
    SECRETO, P
    FAVERO, A
    GALATOLA, G
    EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 1993, 5 (12) : 1037 - 1041
  • [36] Combined analysis of the effect of treatment with ursodeoxycholic acid on histologic progression in primary biliary cirrhosis
    Poupon, RE
    Lindor, KD
    Parés, A
    Chazouillères, O
    Poupon, R
    Heathcote, EJ
    JOURNAL OF HEPATOLOGY, 2003, 39 (01) : 12 - 16
  • [37] Increased intercellular adhesion molecule-1 serum concentration in cholestasis
    Polzien, F
    Ramadori, G
    JOURNAL OF HEPATOLOGY, 1996, 25 (06) : 877 - 886
  • [38] Pentoxifylline, but not ursodeoxycholic acid or tauroursodeoxycholic acid inhibits the proliferative effect of sera samples from primary biliary cirrhosis patients
    Peterson, TC
    Huet, PM
    HEPATOLOGY RESEARCH, 1997, 7 (02) : 94 - 104
  • [39] Bile acid therapy and markers of immune-mediated damage in primary biliary cirrhosis
    deCaestecker, JS
    EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 1997, 9 (02) : 145 - 147
  • [40] Improvement of peripheral blood lymphocyte subsets in primary biliary cirrhosis after ursodeoxycholic acid therapy
    Ikeda, T
    Sato, C
    Noguchi, O
    Kobayashi, F
    Tozuka, S
    Sakamoto, S
    Marumo, F
    JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 1996, 11 (04) : 366 - 372