Highly potent and selective inhibitors of endothelin converting enzyme

被引：25

作者：

Chackalamannil, S

Chung, S

Stamford, AW

McKittrick, BA

Wang, YG

Tsai, HG

Cleven, R

Fawzi, A

Czarniecki, M

机构：

[1] Schering-Plough Research Institute, Kenilworth, NJ 07033

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 11期

关键词：

D O I：

10.1016/0960-894X(96)00211-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Phosphinic acid derivatives, represented by structure 1, have been synthesized and evaluated as endothelin converting enzyme (ECE) inhibitors. Several of these compounds (for example, 1b, 1c, and 1f) were found to be potent inhibitors of ECE with a high degree of selectivity against neutral endopeptidase (NEP). Copyright (C) 1996 Elsevier Science Ltd.

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页码：1257 / 1260

页数：4

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