Mesothelioma: Do asbestos and carbon nanotubes pose the same health risk?

被引:102
作者
Jaurand, Marie-Claude F. [1 ,2 ]
Renier, Annie [1 ,2 ]
Daubriac, Julien [1 ,2 ]
机构
[1] Fondat Jean Dausset CEPH, U674, INSERM, F-75010 Paris, France
[2] Univ Paris 07, F-75013 Paris, France
关键词
STRUCTURAL DEFECTS PLAY; ACUTE LUNG TOXICITY; OXIDATIVE STRESS; DNA-DAMAGE; MALIGNANT MESOTHELIOMA; CROCIDOLITE ASBESTOS; ENVIRONMENTAL EXPOSURE; PLEURAL MESOTHELIOMA; CHROMOSOMAL CHANGES; INHALED ASBESTOS;
D O I
10.1186/1743-8977-6-16
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Carbon nanotubes (CNTs), the product of new technology, may be used in a wide range of applications. Because they present similarities to asbestos fibres in terms of their shape and size, it is legitimate to raise the question of their safety for human health. Recent animal and cellular studies suggest that CNTs elicit tissue and cell responses similar to those observed with asbestos fibres, which increases concern about the adverse biological effects of CNTs. While asbestos fibres' mechanisms of action are not fully understood, sufficient results are available to develop hypotheses about the significant factors underlying their damaging effects. This review will summarize the current state of knowledge about the biological effects of CNTs and will discuss to what extent they present similarities to those of asbestos fibres. Finally, the characteristics of asbestos known to be associated with toxicity will be analyzed to address the possible impact of CNTs.
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页数:14
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