Type 1 diabetes. From biomarkers to prevention

被引：2

作者：

Boitard, Christian ^{[1
]}

机构：

[1] Hop Cochin, Serv Diabetol, 123 Blvd Port Royal, F-75014 Paris, France

来源：

BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE | 2017年 / 201卷 / 1-3期

关键词：

DIABETES MELLITUS; TYPE I; AUTOANTIBODIES; AUTOIMMUNITY; ENVIRONMENT; IMMUNOTHERAPY; NOD MICE; ISLET AUTOANTIBODIES; RISK-FACTORS; BETA-CELLS; PROGRESSION; GENETICS; HUMANS; SYSTEM;

D O I：

10.1016/S0001-4079(19)30527-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type 1 diabetes is an auto-immune disease that leads to the destruction of insulin-secreting cells by the immune system. The auto-immune response to insulin-secreting cells, from the expansion of autoreactive lymphocytes to the activation of effectors involved in the destruction of insulin-secreting cells, has been extensively defined in preclinical models of type 1 diabetes. However, underlying mechanisms initiating the autoimmune process remain ill-defined. The type I diabetes challenge is in relating immune mechanisms involved with new therapeutic strategies that will lead to disease prevention. The identification of new biomarkers is a prerequisite for progress towards preventive strategies.

引用

页码：297 / 307

页数：11

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