Is human leukocyte antigen-matched sibling donor transplant always better than haploidentical allograft?

被引：11
作者：
Chang, Ying-Jun [1 ,2 ]
Huang, Xiao-Jun [1 ,2 ,3 ]
机构：
[1] Peking Univ Peoples Hosp, Beijing, Peoples R China
[2] Peking Univ, Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing, Peoples R China
[3] Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
来源：
SEMINARS IN HEMATOLOGY | 2019年 / 56卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Human leukocyte antigen-matched sibling donor transplantation; Haploidentical stem cell transplantation; Graft-vs-leukemia effects; STEM-CELL TRANSPLANTATION; ACUTE LYMPHOBLASTIC-LEUKEMIA; VERSUS-HOST-DISEASE; BONE-MARROW-TRANSPLANTATION; MINIMAL RESIDUAL DISEASE; ACUTE MYELOID-LEUKEMIA; POSTTRANSPLANTATION CYCLOPHOSPHAMIDE; EUROPEAN-SOCIETY; HODGKIN LYMPHOMA; WORKING PARTY;
D O I：
10.1053/j.seminhematol.2018.07.005
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Currently, haploidentical donor has been an alternative source of stem cell allografts for patients who have no human leukocyte antigen-matched sibling donor or unrelated donors. A number of studies indicated that treating hematological malignancy patients with haploidentical stem cell transplantation (haplo-SCT) could achieve comparable outcomes to those who underwent matched sibling donor transplantation (MSDT). In recent years, more and more evidence support the notion that haploidentical allografts may have a stronger graft-vs-leukemia (GVL) effect than MSDT. In this review, we summarized the transplant outcomes of haplo-SCT and MSDT, mainly focusing on the subgroup of patients who will benefit from the stronger GVL effects of haplo-SCT compared with MSDT. We also offered strategies of how to translate the strong antileukemia activity of haploidentical allograft into superior survival. Future directions of GVL effects in haplo-SCT settings were also discussed. (C) 2018 Published by Elsevier Inc.
引用
收藏
页码：201 / 208
页数：8
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