Understanding anti-leukemia responses to donor lymphocyte infusion

被引：22
作者：
Bachireddy, Pavan
Wu, Catherine J. [1 ]
机构：
[1] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
来源：
ONCOIMMUNOLOGY | 2014年 / 3卷 / 03期
关键词：
T cell exhaustion; donor lymphocyte infusion; CML; stem cell transplantation; tumor-infiltrating lymphocytes; STEM-CELL TRANSPLANTATION; LEUKEMIA; EXHAUSTION; IMMUNITY;
D O I：
10.4161/onci.28187
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Donor lymphocyte infusion (DLI) is an established and potentially curative immune therapy for relapsed leukemia after hematopoietic stem cell transplant (HSCT). Herein, we describe the utility of DLI as a tractable model system to glean fresh insights into understanding and predicting effective anti-leukemia immunity.
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