Vildagliptin ameliorates biochemical, metabolic and fatty changes associated with non alcoholic fatty liver disease

Objective: To determine the effect of Vildagliptin in non-alcoholic, fatty liver disease patients with dyslipidemia. Methods: A randomized placebo controlled trial was conducted at outpatient clinic of Medical Unit-I of Sheikh Zayed Medical College/Hospital, Rahim Yar Khan, in which fifty eight patients of NAFLD with dyslipidemia were divided in to two, case and control groups. The case group was given tablet Vildagliptin 50mg twice a day for twelve weeks and control group was given placebo in same way. Body weight, body mass index (BMI), lipid profile, liver enzymes and ultrasound finding of fatty liver were assayed before and after treatment. Results: After 12 weeks treatment of vildagliptin there was significant improvement in following parameters. Body weight and BMI decreased significantly from 88 +/- 11 to79 +/- 12 kg (p0.036) and 30 +/- 4to 27 +/- 5 kg/m(2) (p 0.005) respectively. Notable reduction in the value of TC, TG and LDL-C (TC: 252 +/- 24 to 220 +/- 20mg/dl (p 0.031); TG:190 +/- 24 to115 +/- 22 mg/dl (p 0.005); LDL-C 160 +/- 15 to 145 +/- 13mg/dl (p 0.004). HDL-C level increased significantly from 29 +/- 5to45 +/- 4 mg/dl (p 0.001).There was remarkable reduction in aminotransferases level (ALT: 78 +/- 17 to 48 +/- 14IU/L (p 0.036). AST: 63.3 +/- 13 to41 +/- 11IU/L (p 0.002). There was overall 65.5% improvement in fatty liver grading on ultrasound with vildagliptin while non significant effects were seen in placebo group in all of the above parameters. Conclusion: Vildagliptin exhibited beneficial effects in non-alcoholic fatty liver disease, Nondiabetic patients with dyslipidemia.