Engrams and circuits crucial for systems consolidation of a memory

被引：680

作者：

Kitamura, Takashi ^{[1
,2
]}

Ogawa, Sachie K. ^{[1
,2
]}

Roy, Dheeraj S. ^{[1
,2
]}

Okuyama, Teruhiro ^{[1
,2
]}

Morrissey, Mark D. ^{[1
,2
]}

Smith, Lillian M. ^{[1
,2
]}

Redondo, Roger L. ^{[1
,2
,3
]}

Tonegawa, Susumu ^{[1
,2
,3
]}

机构：

[1] MIT, RIKEN MIT Ctr Neural Circuit Genet, Picower Inst Learning & Memory, Dept Biol, Cambridge, MA 02139 USA

[2] MIT, RIKEN MIT Ctr Neural Circuit Genet, Picower Inst Learning & Memory, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA

[3] MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA

来源：

SCIENCE | 2017年 / 356卷 / 6333期

关键词：

COMPLEMENTARY LEARNING-SYSTEMS; RETROGRADE-AMNESIA; FEAR; CELLS; HIPPOCAMPUS; REACTIVATION; RETRIEVAL; ENSEMBLES; NEOCORTEX; ABSENCE;

D O I：

10.1126/science.aam6808

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Episodic memories initially require rapid synaptic plasticity within the hippocampus for their formation and are gradually consolidated in neocortical networks for permanent storage. However, the engrams and circuits that support neocortical memory consolidation have thus far been unknown. We found that neocortical prefrontal memory engram cells, which are critical for remote contextual fear memory, were rapidly generated during initial learning through inputs from both the hippocampal-entorhinal cortex network and the basolateral amygdala. After their generation, the prefrontal engram cells, with support from hippocampal memory engram cells, became functionally mature with time. Whereas hippocampal engram cells gradually became silent with time, engram cells in the basolateral amygdala, which were necessary for fear memory, were maintained. Our data provide new insights into the functional reorganization of engrams and circuits underlying systems consolidation of memory.

引用

页码：73 / +

页数：6

共 33 条

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