Ru2(CO)4(OOCR)2(PPh3)2 sawhorse-type complexes containing μ2-η2-carboxylato ligands derived from biologically active acids

被引:14
作者
Auzias, Mathieu [1 ]
Therrien, Bruno [1 ]
Suess-Fink, Georg [1 ]
机构
[1] Univ Neuchatel, Inst Chim, CH-2009 Neuchatel, Switzerland
关键词
carbonyl ligands; carboxylato bridges; biologically active acids; dinuclear complexes; ruthenium;
D O I
10.1016/j.ica.2006.04.015
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
The thermal reaction of Ru-3(CO)(12) with the biologically active acids acetyl salicylic acid (Aspirin), alpha-methyl-4-(isobutyl)phenylacetic acid (Ibuprofen) and 3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholanic acid (cholic acid) in refluxing tetrahydrofuran, followed by addition of triphenylphosphine, gives the dinuclear complexes Ru-2(CO)(4)(OOCR)(2)(PPh3)(2) (1: R = C6H4-2-OCOMe, 2: R = CHMe-C6H4-4-Bu', 3: C23H39O3). The single-crystal structural analysis of 1 and 2 reveals a dinuclear Ru-2(CO)4 sawhorse structure, the diruthenium backbone being bridged by the carboxylato ligands, while the two phosphine ligands occupy the axial positions at the ruthenium atoms. However, chiral carbon atoms in the carboxylic acid undergo racemisation during the thermal reaction. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码:3412 / 3416
页数:5
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