Stem Cell Imaging: From Bench to Bedside

被引：197
作者：
Nguyen, Patricia K. [1 ,2 ,3 ]
Riegler, Johannes [1 ,2 ,3 ]
Wu, Joseph C. [1 ,2 ,3 ,4 ]
机构：
[1] Stanford Univ, Dept Med, Div Cardiol, Stanford, CA 94305 USA
[2] Dept Radiol, Mol Imaging Program, Stanford, CA 94305 USA
[3] Stanford Cardiovasc Inst, Stanford, CA 94305 USA
[4] Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA
来源：
CELL STEM CELL | 2014年 / 14卷 / 04期
关键词：
ACUTE MYOCARDIAL-INFARCTION; MARROW MONONUCLEAR-CELLS; LEFT-VENTRICULAR FUNCTION; MAGNETIC-RESONANCE TRACKING; IN-VIVO TRACKING; INDUCED PLURIPOTENT; REPORTER GENE; ISCHEMIC CARDIOMYOPATHY; ENDOTHELIAL-CELLS; IMMUNE REJECTION;
D O I：
10.1016/j.stem.2014.03.009
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Although cellular therapies hold great promise for the treatment of human disease, results from several initial clinical trials have not shown a level of efficacy required for their use as a first line therapy. Here we discuss how in vivo molecular imaging has helped identify barriers to clinical translation and potential strategies that may contribute to successful transplantation and improved outcomes, with a focus on cardiovascular and neurological diseases. We conclude with a perspective on the future role of molecular imaging in defining safety and efficacy for clinical implementation of stem cell therapies.
引用
收藏
页码：431 / 444
页数：14
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