Copper-Catalyzed C(sp2)-H Amidation with Azides as Amino Sources

被引：110

作者：

Peng, Jiangling ^{[1
]}

Xie, Zeqiang ^{[1
]}

Chen, Ming ^{[1
]}

Wang, Jian ^{[1
]}

Zhu, Qiang ^{[1
]}

机构：

[1] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, State Key Lab Resp Dis, Guangzhou 510530, Guangdong, Peoples R China

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 18期

基金：

美国国家科学基金会;

关键词：

C-H AMIDATION; N BOND FORMATION; DIRECT AMINATION; ORGANIC AZIDES; OXIDATIVE FUNCTIONALIZATION; INTERMOLECULAR AMIDATION; ACYL AZIDES; ARENES; ACTIVATION; CARBAZOLES;

D O I：

10.1021/ol502010g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper-catalyzed C-H amidation process, with azides as amino sources under oxidant-free conditions, has been developed. When N-heterocycles were employed as directing groups, sulfonylazide and benzoylazide could be used as amidating reagents to provide corresponding N-arylamides. When amidines or imine were used, tandem C-N/N-N bond formation occurred to afford indazole derivatives in one pot.

引用

页码：4702 / 4705

页数：4

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