Long-Term Diet Supplementation with Lactobacillus paracasei K71 Prevents Age-Related Cognitive Decline in Senescence-Accelerated Mouse Prone 8

被引:56
作者
Corpuz, Henry M. [1 ,2 ]
Ichikawa, Saki [3 ]
Arimura, Misa [3 ]
Mihara, Toshihiro [4 ]
Kumagai, Takehisa [4 ]
Mitani, Takakazu [5 ]
Nakamura, Soichiro [1 ]
Katayama, Shigeru [1 ,5 ]
机构
[1] Shinshu Univ, Interdisciplinary Grad Sch Sci & Technol, 8304 Minamiminowa, Nagano 3994598, Japan
[2] Philippine Rice Res Inst, Rice Chem & Food Sci Div, Sci City Of Munoz 3119, Nueva Ecija, Philippines
[3] Shinshu Univ, Fac Agr, 8304 Minamiminowa, Nagano 3994598, Japan
[4] Kameda Seika Co Ltd, Konan Ku, 3-1-1 Kameda Kogyodanchi, Niigata, Niigata 9500198, Japan
[5] Shinshu Univ, Interdisciplinary Cluster Cutting Edge Res, 8304 Minamiminowa, Nagano 3994598, Japan
关键词
probiotics; Lactobacillus paracasei; cognitive dysfunction; brain-derived neurotrophic factor; serotonin; GUT MICROBIOTA; NEUROTROPHIC FACTORS; SEROTONERGIC SYSTEM; ALZHEIMERS-DISEASE; MONOAMINE-OXIDASE; PARALLEL-GROUP; DOUBLE-BLIND; BRAIN; SAMP8; MICE;
D O I
10.3390/nu10060762
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
This study aimed to assess the suppressive effect of long-term diet supplementation with Lactobacillus strains on cognitive decline in the senescence-accelerated mouse prone 8 (SAMP8) model. For 43 weeks, fourteen-week-old female SAMP8 mice were fed a standard diet containing 0.05% (w/w) Lactobacillus casei subsp. casei 327 (L. 327) or Lactobacillusparacasei K71 (L. K71) derived from rice grains and sake lees, respectively. SAMP8 mice that were fed a L. K71-supplemented diet had better cognitive performance compared with the control and L. 327 groups in the Barnes maze and passive avoidance tests. An ELISA analysis revealed that the levels of serotonin were elevated in the serum and brain tissue of L. K71-fed mice. The protein expression levels of brain-derived neurotrophic factor (BDNF), cAMP response element binding protein (CREB), and phosphorylated CREB were evaluated using western blot. Long-term administration of L. K71 resulted in increased protein expression of BDNF and CREB phosphorylation in the hippocampus. These results suggest that prolonged intake of a diet supplemented with a Lactobacillus strain derived from sake lees may prevent age-dependent cognitive decline by upregulating BDNF expression in the hippocampus.
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页数:13
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共 36 条
[21]   Long-term intake of Lactobacillus paracasei KW3110 prevents age-related chronic inflammation and retinal cell loss in physiologically aged mice [J].
Morita, Yuji ;
Jounai, Kenta ;
Sakamoto, Akihiko ;
Tomita, Yasuyuki ;
Sugihara, Yoshihiko ;
Suzuki, Hiroaki ;
Ohshio, Konomi ;
Otake, Masato ;
Fujiwara, Daisuke ;
Kanauchi, Osamu ;
Maruyama, Mitsuo .
AGING-US, 2018, 10 (10) :2723-2740
[22]   Long-Term Testosterone Supplementation in Older Men Attenuates Age-Related Decline in Aerobic Capacity [J].
Traustadottir, Tinna ;
Harman, S. Mitchell ;
Tsitouras, Panayiotis ;
Pencina, Karol M. ;
Li, Zhuoying ;
Travison, Thomas G. ;
Eder, Richard ;
Miciek, Renee ;
McKinnon, Jennifer ;
Woodbury, Erin ;
Basaria, Shehzad ;
Bhasin, Shalender ;
Storer, Thomas W. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2018, 103 (08) :2861-2869
[23]   Chronic administration of N-acetyl-D-mannosamine improves age-associated impairment of long-term potentiation in the senescence-accelerated mouse [J].
Taniguchi, Sakiko ;
Kuwahara, Masayoshi ;
Ito, Koichi .
NEUROSCIENCE LETTERS, 2015, 598 :41-46
[24]   Long-term cilostazol administration prevents age-related decline of hippocampus-dependent memory in mice [J].
Yanai, Shuichi ;
Ito, Hideki ;
Endo, Shogo .
NEUROPHARMACOLOGY, 2018, 129 :57-68
[25]   Association of Lifelong Intake of Barley Diet with Healthy Aging: Changes in Physical and Cognitive Functions and Intestinal Microbiome in Senescence-Accelerated Mouse-Prone 8 (SAMP8) [J].
Shimizu, Chikako ;
Wakita, Yoshihisa ;
Kihara, Makoto ;
Kobayashi, Naoyuki ;
Tsuchiya, Youichi ;
Nabeshima, Toshitaka .
NUTRIENTS, 2019, 11 (08)
[26]   LONG-TERM GREEN TEA CATECHIN ADMINISTRATION PREVENTS SPATIAL LEARNING AND MEMORY IMPAIRMENT IN SENESCENCE-ACCELERATED MOUSE PRONE-8 MICE BY DECREASING Aβ1-42 OLIGOMERS AND UPREGULATING SYNAPTIC PLASTICITY-RELATED PROTEINS IN THE HIPPOCAMPUS [J].
Li, Q. ;
Zhao, H. F. ;
Zhang, Z. F. ;
Liu, Z. G. ;
Pei, X. R. ;
Wang, J. B. ;
Li, Y. .
NEUROSCIENCE, 2009, 163 (03) :741-749
[27]   Triggering receptor expressed on myeloid cells 2 knockdown exacerbates aging-related neuroinflammation and cognitive deficiency in senescence-accelerated mouse prone 8 mice [J].
Jiang, Teng ;
Yu, Jin-Tai ;
Zhu, Xi-Chen ;
Tan, Meng-Shan ;
Gu, Li-Ze ;
Zhang, Ying-Dong ;
Tan, Lan .
NEUROBIOLOGY OF AGING, 2014, 35 (06) :1243-1251
[28]   Long-Term Music Exposure Prevents Age-Related Cognitive Deficits in Rats Independently of Hippocampal Neurogenesis [J].
Rizzolo, Lou ;
Leger, Marianne ;
Corvaisier, Sophie ;
Groussard, Mathilde ;
Platel, Herve ;
Bouet, Valentine ;
Schumann-Bard, Pascale ;
Freret, Thomas .
CEREBRAL CORTEX, 2021, 31 (01) :620-634
[29]   Downregulated Nuclear Factor E2-Related Factor 2 (Nrf2) Aggravates Cognitive Impairments via Neuroinflammation and Synaptic Plasticity in the Senescence-Accelerated Mouse Prone 8 (SAMP8) Mouse: A Model of Accelerated Senescence [J].
Ren, Hui Ling ;
Lv, Chao Nan ;
Xing, Ying ;
Geng, Yuan ;
Zhang, Feng ;
Bu, Wei ;
Wang, Ming Wei .
MEDICAL SCIENCE MONITOR, 2018, 24 :1132-1144
[30]   Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation [J].
d'Avila, Joana Costa ;
Siqueira, Luciana Domett ;
Mazeraud, Aurelien ;
Azevedo, Estefania Pereira ;
Foguel, Debora ;
Castro-Faria-Neto, Hugo Caire ;
Sharshar, Tarek ;
Chretien, Fabrice ;
Bozza, Fernando Augusto .
JOURNAL OF NEUROINFLAMMATION, 2018, 15