Long-Term Diet Supplementation with Lactobacillus paracasei K71 Prevents Age-Related Cognitive Decline in Senescence-Accelerated Mouse Prone 8

被引:56
作者
Corpuz, Henry M. [1 ,2 ]
Ichikawa, Saki [3 ]
Arimura, Misa [3 ]
Mihara, Toshihiro [4 ]
Kumagai, Takehisa [4 ]
Mitani, Takakazu [5 ]
Nakamura, Soichiro [1 ]
Katayama, Shigeru [1 ,5 ]
机构
[1] Shinshu Univ, Interdisciplinary Grad Sch Sci & Technol, 8304 Minamiminowa, Nagano 3994598, Japan
[2] Philippine Rice Res Inst, Rice Chem & Food Sci Div, Sci City Of Munoz 3119, Nueva Ecija, Philippines
[3] Shinshu Univ, Fac Agr, 8304 Minamiminowa, Nagano 3994598, Japan
[4] Kameda Seika Co Ltd, Konan Ku, 3-1-1 Kameda Kogyodanchi, Niigata, Niigata 9500198, Japan
[5] Shinshu Univ, Interdisciplinary Cluster Cutting Edge Res, 8304 Minamiminowa, Nagano 3994598, Japan
关键词
probiotics; Lactobacillus paracasei; cognitive dysfunction; brain-derived neurotrophic factor; serotonin; GUT MICROBIOTA; NEUROTROPHIC FACTORS; SEROTONERGIC SYSTEM; ALZHEIMERS-DISEASE; MONOAMINE-OXIDASE; PARALLEL-GROUP; DOUBLE-BLIND; BRAIN; SAMP8; MICE;
D O I
10.3390/nu10060762
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
This study aimed to assess the suppressive effect of long-term diet supplementation with Lactobacillus strains on cognitive decline in the senescence-accelerated mouse prone 8 (SAMP8) model. For 43 weeks, fourteen-week-old female SAMP8 mice were fed a standard diet containing 0.05% (w/w) Lactobacillus casei subsp. casei 327 (L. 327) or Lactobacillusparacasei K71 (L. K71) derived from rice grains and sake lees, respectively. SAMP8 mice that were fed a L. K71-supplemented diet had better cognitive performance compared with the control and L. 327 groups in the Barnes maze and passive avoidance tests. An ELISA analysis revealed that the levels of serotonin were elevated in the serum and brain tissue of L. K71-fed mice. The protein expression levels of brain-derived neurotrophic factor (BDNF), cAMP response element binding protein (CREB), and phosphorylated CREB were evaluated using western blot. Long-term administration of L. K71 resulted in increased protein expression of BDNF and CREB phosphorylation in the hippocampus. These results suggest that prolonged intake of a diet supplemented with a Lactobacillus strain derived from sake lees may prevent age-dependent cognitive decline by upregulating BDNF expression in the hippocampus.
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页数:13
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共 33 条
[1]   Monoamine oxidase inactivation: From pathophysiology to therapeutics [J].
Bortolato, Marco ;
Chen, Kevin ;
Shih, Jean C. .
ADVANCED DRUG DELIVERY REVIEWS, 2008, 60 (13-14) :1527-1533
[2]   The senescence-accelerated prone mouse (SAMP8): A model of age-related cognitive decline with relevance to alterations of the gene expression and protein abnormalities in Alzheimer's disease [J].
Butterfield, DA ;
Poon, HF .
EXPERIMENTAL GERONTOLOGY, 2005, 40 (10) :774-783
[3]   The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner [J].
Clarke, G. ;
Grenham, S. ;
Scully, P. ;
Fitzgerald, P. ;
Moloney, R. D. ;
Shanahan, F. ;
Dinan, T. G. ;
Cryan, J. F. .
MOLECULAR PSYCHIATRY, 2013, 18 (06) :666-673
[4]   Brain-Derived Neurotrophic Factor and the Development of Structural Neuronal Connectivity [J].
Cohen-Cory, Susana ;
Kidane, Adhanet H. ;
Shirkey, Nicole J. ;
Marshak, Sonya .
DEVELOPMENTAL NEUROBIOLOGY, 2010, 70 (05) :271-288
[5]   Modulation of Intestinal Microbiota by the Probiotic VSL#3 Resets Brain Gene Expression and Ameliorates the Age-Related Deficit in LTP [J].
Distrutti, Eleonora ;
O'Reilly, Julie-Ann ;
McDonald, Claire ;
Cipriani, Sabrina ;
Renga, Barbara ;
Lynch, Marina A. ;
Fiorucci, Stefano .
PLOS ONE, 2014, 9 (09)
[6]  
Flood JF, 1998, NEUROSCI BIOBEHAV R, V22, P1
[7]   THE EFFECT OF AGE ON THE ACTIVITY AND MOLECULAR-PROPERTIES OF HUMAN-BRAIN MONOAMINE-OXIDASE [J].
FOWLER, CJ ;
WIBERG, A ;
ORELAND, L ;
MARCUSSON, J ;
WINBLAD, B .
JOURNAL OF NEURAL TRANSMISSION, 1980, 49 (1-2) :1-20
[8]   New Insights in the Biology of BDNF Synthesis and Release: Implications in CNS Function [J].
Greenberg, Michael E. ;
Xu, Baoji ;
Lu, Bai ;
Hempstead, Barbara L. .
JOURNAL OF NEUROSCIENCE, 2009, 29 (41) :12764-12767
[9]   Drinking Hydrogen Water Ameliorated Cognitive Impairment in Senescence-Accelerated Mice [J].
Gu, Yeunhwa ;
Huang, Chien-Sheng ;
Inoue, Tota ;
Yamashita, Takenori ;
Ishida, Torao ;
Kang, Ki-Mun ;
Nakao, Atsunori .
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 2010, 46 (03) :269-276
[10]   COUPLING OF HORMONAL-STIMULATION AND TRANSCRIPTION VIA THE CYCLIC AMP-RESPONSIVE FACTOR CREB IS RATE LIMITED BY NUCLEAR ENTRY OF PROTEIN KINASE-A [J].
HAGIWARA, M ;
BRINDLE, P ;
HAROOTUNIAN, A ;
ARMSTRONG, R ;
RIVIER, J ;
VALE, W ;
TSIEN, R ;
MONTMINY, MR .
MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (08) :4852-4859