Cross-Talk Between Notch and EGFR Signaling in Human Breast Cancer Cells

被引：32

作者：

Dai, Jianjian ^{[1
]}

Ma, Daoxin ^{[1
]}

Zang, Shaolei ^{[1
]}

Guo, Dongmei ^{[1
]}

Qu, Xun ^{[2
]}

Ye, Jingjing ^{[1
]}

Ji, Chunyan ^{[1
]}

机构：

[1] Shandong Univ, Dept Hematol, Qilu Hosp, Jinan 250012, Shandong, Peoples R China

[2] Shandong Univ, Inst Basic Med Sci, Qilu Hosp, Jinan 250012, Shandong, Peoples R China

来源：

CANCER INVESTIGATION | 2009年 / 27卷 / 05期

基金：

芬兰科学院;

关键词：

Human breast cancer; Notch1; EGFR inhibitor; Proliferation; Apoptosis; GROWTH-FACTOR RECEPTOR; ESTROGEN-RECEPTOR; PANCREATIC-CANCER; DOWN-REGULATION; TUMOR-CELLS; ACTIVATION; GEFITINIB; PATHWAYS; ANGIOGENESIS; COEXPRESSION;

D O I：

10.1080/07357900802563036

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Notch and epidermal growth factor receptor (EGFR) signaling play critical roles in cell proliferation, differentiation, and apoptosis, and thereby may contribute to the development of breast cancer. We constitutively overexpressed active Notch1 in human breast cancer cells to explore the consequences of Notch1 signaling on cell growth and to investigate the underlying molecular mechanisms. We found that EGFR expression was increased. Then, using EGFR inhibitor, we found it exhibited an inhibitory role on human breast cancer cells. Overexpression of Notch1 could reverse EGFR inhibitor-induced cell toxicity, suggesting that Notch and EGFR signaling may be positively cross-linked in human breast cancer.

引用

页码：533 / 540

页数：8

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