Effect of Ca2+ on presynaptic facilitation

被引：0
作者：
Bykhovskaia, M [1 ]
Polagaeva, E [1 ]
Hackett, JT [1 ]
机构：
[1] Univ Virginia, Dept Mol Physiol, Hlth Sci Ctr, Charlottesville, VA 22908 USA
来源：
NEUROCOMPUTING | 2002年 / 44卷
关键词：
intracellular Ca2+; synaptic transmission; neuromuscular junction; releasable pool of synaptic vesicles; neurosecretion;
D O I：
10.1016/S0925-2312(02)00348-X
中图分类号：
TP18 [人工智能理论];
学科分类号：
081104 ; 0812 ; 0835 ; 1405 ;
摘要：
We investigated and modeled the effect of Ca2+ on presynaptic facilitation. Facilitation of transmitter release from a presynaptic terminal is believed to arise from the local increase of Ca2+ concentration. We measured and simulated the effect of Ca2+ on facilitation at the lobster neuromuscular synapse. Facilitation was measured using quantal analysis of postsynaptic potentials recorded focally during trains of stimuli. We found a facilitation component, which was not affected by Ca2+ concentration. Transmitter release was simulated using a model of two pools of presynaptic vesicles available for release. The simulation reproduced quantitatively Ca2+-dependent and Ca2+-independent components of facilitation. (C) 2002 Elsevier Science B.V. All rights reserved.
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页码：1 / 5
页数：5
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