The neuroprotective roles of Dietary Micronutrients on Parkinson's disease: a review

被引：8

作者：

Rahimmi, Arman ^{[1
,2
]}

Tozandehjani, Sima ^{[3
]}

Daraei, Mona ^{[4
]}

Khademerfan, Mohammadbagher ^{[1
,2
]}

机构：

[1] Kurdistan Univ Med Sci, Fac Med, Dept Mol Med, Sanandaj, Iran

[2] Kurdistan Univ Med Sci, Cellular & Mol Res Ctr, Res Inst Hlth Dev, Sanandaj, Iran

[3] Kurdistan Univ, Dept Biol Sci, Sanandaj, Iran

[4] Ahvaz Jundishapur Univ Med Sci, Arvand Int Div, Ahvaz, Iran

来源：

MOLECULAR BIOLOGY REPORTS | 2022年 / 49卷 / 08期

关键词：

Parkinson's disease; Oxidative stress; Antioxidants; Anti-inflammation; Micronutrients; DOPAMINERGIC NEURODEGENERATION; OXIDATIVE STRESS; MOUSE MODEL; MPTP MODEL; VITAMIN-E; RAT; NEURONS; THYMOQUINONE; RESVERATROL; ACTIVATION;

D O I：

10.1007/s11033-022-07345-w

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Parkinson's disease (PD) is a prevalent elderly neurodegenerative disease. The nature of PD is strongly bounded with certain cellular processes, including oxidative stress, neuro-inflammation, apoptosis, and mitochondrial dysfunction. Therefore, many clinical and pre-clinical studies have reported protective effects of certain dietary micronutrients for PD. Hence, this review tried to introduce a series of important dietary micronutrients, which to our best of knowledge, were among those compounds known as beneficial for PD with a high consensus. The compounds possess neuroprotective properties (e.g. anti-oxidation, anti-inflammation, anti-apoptosis, boosting mitochondrial performance, regulating autophagy process). Thus, the compounds probably may act on several cellular targets to prevent the development of PD or to attenuate the progress of the disease. Investigating these compounds probably can lead to the development of novel supplementary therapeutic approaches, as well as refinement of dietary regimen of PD patients.

引用

页码：8051 / 8060

页数：10