RE: Inhibition of apoptosis signal-regulating kinase 1 might be a novel therapeutic target in the treatment of cardiorenal syndrome

被引：0

作者：

Savira, Feby ^{[1
,2
]}

Edgley, Amanda J. ^{[3
]}

Jucker, Beat M. ^{[4
]}

Willette, Robert N. ^{[4
]}

Krum, Henry ^{[2
]}

Kelly, Darren J. ^{[3
]}

Kompa, Andrew R. ^{[2
,3
]}

Wang, Bing H. ^{[1
,2
]}

机构：

[1] Baker Heart & Diabet Res Inst, Biomarker Discovery Lab, Melbourne, Vic, Australia

[2] Monash Univ, Sch Publ Hlth & Prevent Med, Ctr Cardiovasc Res & Educ Therapeut, Melbourne, Vic, Australia

[3] Univ Melbourne, St Vincents Hosp, Dept Med, Fitzroy, Vic, Australia

[4] GlaxoSmithKline, Heart Failure Discovery Performance Unit, King Of Prussia, PA USA

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2021年 / 323卷

基金：

英国医学研究理事会;

关键词：

HYPERTROPHY; FIBROSIS;

D O I：

10.1016/j.ijcard.2020.09.021

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：260 / 260

页数：1

共 9 条

[1] Dickkopf-3 protects against cardiac dysfunction and ventricular remodelling following myocardial infarction [J].

Bao, Ming-Wei ;

Cai, Zhongxiang ;

Zhang, Xiao-Jing ;

Li, Liangpeng ;

Liu, Xiaoxiong ;

Wan, Nian ;

Hu, Gangying ;

Wan, Fengwei ;

Zhang, Rui ;

Zhu, Xueyong ;

Xia, Hao ;

Li, Hongliang .

BASIC RESEARCH IN CARDIOLOGY, 2015, 110 (03)

[2] Effects of Selonsertib in Patients with Diabetic Kidney Disease [J].

Chertow, Glenn M. ;

Pergola, Pablo E. ;

Chen, Fang ;

Kirby, Brian J. ;

Sundy, John S. ;

Patel, Uptal D. .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2019, 30 (10) :1980-1990

[3] Higenamine Improves Cardiac and Renal Fibrosis in Rats With Cardiorenal Syndrome via ASK1 Signaling Pathway [J].

Deng, Ting ;

Wei, Zhenming ;

Gael, Akindavyi ;

Deng, Xiaofang ;

Liu, Yunfeng ;

Lai, Jun ;

Hang, Liwei ;

Yan, Quanneng ;

Fu, Qiang ;

Li, Zhiliang .

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2020, 75 (06) :535-544

[4] Apoptosis signal-regulating kinase 1 plays a pivotal role in angiotensin II - Induced cardiac hypertrophy and remodeling [J].

Izumiya, Y ;

Kim, S ;

Izumi, Y ;

Yoshida, K ;

Yoshiyama, M ;

Matsuzawa, A ;

Ichijo, H ;

Iwao, H .

CIRCULATION RESEARCH, 2003, 93 (09) :874-883

[5] ASK1 Regulates Cardiomyocyte Death but Not Hypertrophy in Transgenic Mice [J].

Liu, Qinghang ;

Sargent, Michelle A. ;

York, Allen J. ;

Molkentin, Jeffery D. .

CIRCULATION RESEARCH, 2009, 105 (11) :1110-U140

[6] The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: A randomized, phase 2 trial [J].

Loomba, Rohit ;

Lawitz, Eric ;

Mantry, Parvez S. ;

Jayakumar, Saumya ;

Caldwell, Stephen H. ;

Arnold, Hays ;

Diehl, Anna Mae ;

Djedjos, C. Stephen ;

Han, Ling ;

Myers, Robert P. ;

Subramanian, G. Mani ;

McHutchison, John G. ;

Goodman, Zachary D. ;

Afdhal, Nezam H. ;

Charlton, Michael R. .

HEPATOLOGY, 2018, 67 (02) :549-559

[7] Inhibition of apoptosis signal-regulating kinase 1 ameliorates left ventricular dysfunction by reducing hypertrophy and fibrosis in a rat model of cardiorenal syndrome [J].

Savira, Feby ;

Wang, Bing H. ;

Edgley, Amanda J. ;

Jucker, Beat M. ;

Willette, Robert N. ;

Krum, Henry ;

Kelly, Darren J. ;

Kompa, Andrew R. .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2020, 310 :128-136

[8] Apoptosis signal-regulating kinase 1/p38 signaling pathway negatively regulates physiological hypertrophy [J].

Taniike, Masayuki ;

Yamaguchi, Osamu ;

Tsujimoto, Ikuko ;

Hikoso, Shungo ;

Takeda, Toshihiro ;

Nakai, Atsuko ;

Omiya, Shigemiki ;

Mizote, Isamu ;

Nakano, Yuko ;

Higuchi, Yoshiharu ;

Matsumura, Yasushi ;

Nishida, Kazuhiko ;

Ichijo, Hidenori ;

Hori, Masatsugu ;

Otsu, Kinya .

CIRCULATION, 2008, 117 (04) :545-552

[9]

Yang W., 2017, HEART LUNG CIRC, VS1443-9506, P31522

← 1 →